Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain

John P M White, Mario Cibelli, Antonio Rei Fidalgo, Cleoper C. Paule, Faruq Noormohamed, Laszlo Urban, Mervyn Maze, I. Nagy

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Pain originating in inflammation is the most common pathologic pain condition encountered by the anesthesiologist whether in the context of surgery, its aftermath, or in the practice of pain medicine. Inflammatory agents, released as components of the body's response to peripheral tissue damage or disease, are now known to be collectively capable of activating transient receptor potential vanilloid type 1, transient receptor potential vanilloid type 4, transient receptor potential ankyrin type 1, and acid-sensing ion channels, whereas individual agents may activate only certain of these ion channels. These ionotropic receptors serve many physiologic functions-as, indeed, do many of the inflammagens released in the inflammatory process. Here, we introduce the reader to the role of these ionotropic receptors in mediating peripheral pain in response to inflammation.

Original languageEnglish
Pages (from-to)729-741
Number of pages13
JournalAnesthesiology
Volume112
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Acid Sensing Ion Channels
Pain
Ankyrins
Inflammation
Ion Channels
Medicine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

White, J. P. M., Cibelli, M., Rei Fidalgo, A., Paule, C. C., Noormohamed, F., Urban, L., ... Nagy, I. (2010). Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. Anesthesiology, 112(3), 729-741. https://doi.org/10.1097/ALN.0b013e3181ca3179

Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. / White, John P M; Cibelli, Mario; Rei Fidalgo, Antonio; Paule, Cleoper C.; Noormohamed, Faruq; Urban, Laszlo; Maze, Mervyn; Nagy, I.

In: Anesthesiology, Vol. 112, No. 3, 03.2010, p. 729-741.

Research output: Contribution to journalArticle

White, JPM, Cibelli, M, Rei Fidalgo, A, Paule, CC, Noormohamed, F, Urban, L, Maze, M & Nagy, I 2010, 'Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain', Anesthesiology, vol. 112, no. 3, pp. 729-741. https://doi.org/10.1097/ALN.0b013e3181ca3179
White JPM, Cibelli M, Rei Fidalgo A, Paule CC, Noormohamed F, Urban L et al. Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. Anesthesiology. 2010 Mar;112(3):729-741. https://doi.org/10.1097/ALN.0b013e3181ca3179
White, John P M ; Cibelli, Mario ; Rei Fidalgo, Antonio ; Paule, Cleoper C. ; Noormohamed, Faruq ; Urban, Laszlo ; Maze, Mervyn ; Nagy, I. / Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. In: Anesthesiology. 2010 ; Vol. 112, No. 3. pp. 729-741.
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