Role of TNF-α and its 55 and 75 kDa receptors in bronchial hyperreactivity

A. Halász, E. Cserháti, P. Magyar, M. Kovács, K. Cseh

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The pathophysiological role of the tumour necrosis factor (TNF) system was studied in adults (n=37) and children (n=43) non asthmatic offspring of asthmatic parents with and without bronchial hyperreactivity proved by methacholine airway challenge test. Serum TNFα and its soluble receptors (sTNF-R1 and R2) were determined by enzyme-linked immunosorbent assay (ELISA). Significantly elevated TNFα (adults: mean ± SD=5.18 ± 0.87 pg ml-1, children: 5.08 ± 1.78) vs. non-hyperreactives (adults: 4.12 ± 0.43, P < 0.0001, children: 3.75 ± 0.68, P=0.0084), sTNF-RI (adults: 1.44 ± 0.31 ng ml-1, children: 1.30 ± 0.25 vs. adults: 1.21 ± 0.14, P=0.0305, children: 1.13 ± 0.11 ng ml-1, P=0.0042) and sTNF-R2 (adults: 0.85 ± 0.40 ng ml-1, children: 0.70 ± 0.46 vs. adults: 0.56 ± 0.56 P=0.0084, children: 0.33 ± 0.17, P=0.0048) and decreased sTNF-R1/R2 ratio (adults: mean ± SD=0.96 ± 0.73, children: 2.85 ± 2.06 vs. adults: 4.82 ± 3.40, P=0.0272, children: 4.42 ± 2.30, P=0.0167) were measured in patients with bronchial hyperreactivity. The provocation doses of methacholine causing a 20% reduction (PD20) in forced expiratory volume in 1 sec (FEV1) were found to be in a significant negative linear correlation with TNFα, sTNF-R1 and R2 levels in hyperreactive adults and with TNFα, sTNF-R2 in hyperreactive children. TNFα correlated significantly with its receptors both in hyperreactive adults and children and with the body mass index (BMI) values of adults. The TNF system may contribute to the pathophysiology of bronchial hyperreactivity. Altered shedding of sTNF-RI seems to occur in hyperreactive patients.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalRespiratory Medicine
Volume96
Issue number4
DOIs
Publication statusPublished - Apr 2002

Keywords

  • Bronchial asthma
  • Bronchial hyperreactivity
  • TNFα
  • sTNF-R2
  • sTNF-RI

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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