Role of thromboelastography and rapid thromboelastography to assess the pharmacodynamic effects of vitamin K antagonists

Francesco Franchi, Jafri Syed Hammad, Fabiana Rollini, Antonio Tello-Montoliu, Ronakkumar Patel, Andrew Darlington, D. Kraemer, Jung Rae Cho, Christopher DeGroat, Mona Bhatti, Mohamad Taha, Dominick J. Angiolillo

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Abstract

Thromboelastography (TEG) measures the effects of antithrombotic agents by assessing global functional clotting status by evaluating the viscoelastic properties of in vitro clot formation. Recently, rapid TEG (r-TEG), which uses tissue factor in addition to standard kaolin to accelerate activation of the clotting cascade, has been proposed to obtain more immediate results. The correlation between results of TEG or r-TEG with international normalized ratio (INR) in patients on vitamin K antagonist (VKA) therapy has not been explored and represents the aim of this study. Patients on chronic therapy with VKAs (n = 100) were included in an observational prospective pharmacodynamic study. The correlation between TEG parameters, in particular markers of thrombus generation [Reaction time (R), maximum rate of thrombus generation (MRTG), and time to maximum rate of thrombus generation (TMRTG)], and INR values as well as the concordance between these parameters and therapeutic INR ranges were evaluated. In addition, in a subgroup of subjects (n = 17), the correlation of r-TEG parameters with TEG parameters and INR values was also assessed. No correlation was found between INR and TEG parameters of thrombus generation, in particular between INR and R (r = 0.189, p = 0.06), MRTG (r = −0.027, p = 0.79), and TMRTG (r = 0.188, p = 0.06). Further, no concordance was found between these parameters and recommended INR ranges. Significant Spearman correlations were found between INR and activated clotting time (rS = 0.546, p S = 0.572, p = 0.017), and r-TMRTG (rS = 0.510, p = 0.037), but not r-MRTG (rS = 0.131, p = 0.617). Results were obtained in 24 ± 6 versus 12 ± 4 min with TEG and r-TEG, respectively (p 

Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalJournal of Thrombosis and Thrombolysis
Volume40
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

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Keywords

  • Anticoagulant
  • International normalized ratio
  • Thromboelastography
  • Warfarin

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Franchi, F., Hammad, J. S., Rollini, F., Tello-Montoliu, A., Patel, R., Darlington, A., Kraemer, D., Cho, J. R., DeGroat, C., Bhatti, M., Taha, M., & Angiolillo, D. J. (2015). Role of thromboelastography and rapid thromboelastography to assess the pharmacodynamic effects of vitamin K antagonists. Journal of Thrombosis and Thrombolysis, 40(1), 118-125. https://doi.org/10.1007/s11239-014-1130-1