Role of the peroxynitrite - Poly (ADP-ribose) polymerase pathway in the pathogenesis of liver injury

Domokos Gero, Csaba Szabó

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Oxidative and nitrosative stress triggers DNA strand breakage, which then activates the nuclear enzyme poly(ADP-ribose) polymerase (PARP). One of the key triggers of DNA single strand breakage in pathophysiological conditions is peroxynitrite, a reactive species produced from the reaction of nitric oxide and superoxide. Activation of PARP can dramatically lower the intracellular concentration of its substrate, nicotinamide adenine dinucleotide, thus slowing the rate of glycolysis, electron transport and subsequently ATP formation. This process can result in cell dysfunction and cell death. Here we review the role of PARP in various forms of liver injury.

Original languageEnglish
Pages (from-to)2903-2910
Number of pages8
JournalCurrent pharmaceutical design
Volume12
Issue number23
DOIs
Publication statusPublished - Aug 1 2006

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Keywords

  • Hepatic
  • Liver
  • Nitric oxide
  • Peroxynitrite
  • Reperfusion
  • Sepsis
  • Superoxide

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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