Role of the cytoskeleton in the Fc receptor activity of rat peritoneal macrophages

Gabriella Fóris, Balázs Dezső, György Medgyesi, Hervé Bazin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

High concentration of cytochalasin B (CB) and vinblastine (Vb) inhibited the erythrocyte-antibody (EA) rosette formation of rat peritoneal macrophages (PM). Low concentration of Vb enhanced rosette formation. CB and Vb had the same effect on the rosette formation when anti-SRBC immunoglobulin (Ig) had been previously bound in vivo or in vitro to the Fc receptors (FcR) of the macrophages, suggesting that the intact function of the cytoskeleton is required for the last step of rosette formation. CB and Vb exert a reversible effect on FcR activity. Regeneration of FcR activity was observed also in the presence of 10 µg/ml cycloheximide. The effect of CB and Vb on rosette formation depends both on the (sub)classes of antibody involved and on the nature of the particulate antigen. Rosettes with living trypanosomes displayed an extremely high CB sensitivity.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalInternational archives of allergy and immunology
Volume65
Issue number2
DOIs
Publication statusPublished - Jan 1 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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