Role of sulfur site in metal binding to thiopurine and thiopyrimidine nucleosides

Teresa Kowalik-Jankowska, Katalin Varnagy, Jolanta Światek-Kozłowska, Ana Jon, Imre Sovago, Elzbieta Sochacka, Andrzej Malkiewicz, Jan Spychała, Henryk Kozłowski

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Thiolation of uridine and purine bases leads to the formation of very effective ligands for Cd(II) and Ni(II) ions. Potentiometric and spectroscopic studies have shown that the substitution of oxygen by sulfur in uridine, which is a poor ligand for most metal ions, allows thiouridine to strongly bind both Cd(II) and Ni(II) ions. The [N, S] chelation is observed for thiopurines and thiouridines, even if the [S, N(3)] chelation in uridine derivatives leads to the formation of a thermodynamically unfavorable four- member chelate ring. Metal complexes with thiopurine with a five-member chelate ring are, however, considerably more stable (up to 3.5 orders of magnitude) than those of thiouridines.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume65
Issue number4
DOIs
Publication statusPublished - Jan 1 1997

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Role of sulfur site in metal binding to thiopurine and thiopyrimidine nucleosides'. Together they form a unique fingerprint.

  • Cite this

    Kowalik-Jankowska, T., Varnagy, K., Światek-Kozłowska, J., Jon, A., Sovago, I., Sochacka, E., Malkiewicz, A., Spychała, J., & Kozłowski, H. (1997). Role of sulfur site in metal binding to thiopurine and thiopyrimidine nucleosides. Journal of Inorganic Biochemistry, 65(4), 257-262. https://doi.org/10.1016/S0162-0134(96)00140-7