Role of sulfur site in metal binding to thiopurine and thiopyrimidine nucleosides

Teresa Kowalik-Jankowska, K. Várnagy, Jolanta Światek-Kozłowska, Ana Jon, I. Sóvágó, Elzbieta Sochacka, Andrzej Malkiewicz, Jan Spychała, Henryk Kozłowski

Research output: Contribution to journalArticle

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Abstract

Thiolation of uridine and purine bases leads to the formation of very effective ligands for Cd(II) and Ni(II) ions. Potentiometric and spectroscopic studies have shown that the substitution of oxygen by sulfur in uridine, which is a poor ligand for most metal ions, allows thiouridine to strongly bind both Cd(II) and Ni(II) ions. The [N, S] chelation is observed for thiopurines and thiouridines, even if the [S, N(3)] chelation in uridine derivatives leads to the formation of a thermodynamically unfavorable four- member chelate ring. Metal complexes with thiopurine with a five-member chelate ring are, however, considerably more stable (up to 3.5 orders of magnitude) than those of thiouridines.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume65
Issue number4
DOIs
Publication statusPublished - 1997

Fingerprint

Thiouridine
Uridine
Nucleosides
Sulfur
Metals
Ions
Chelation
Ligands
Coordination Complexes
Metal ions
Substitution reactions
Oxygen
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Role of sulfur site in metal binding to thiopurine and thiopyrimidine nucleosides. / Kowalik-Jankowska, Teresa; Várnagy, K.; Światek-Kozłowska, Jolanta; Jon, Ana; Sóvágó, I.; Sochacka, Elzbieta; Malkiewicz, Andrzej; Spychała, Jan; Kozłowski, Henryk.

In: Journal of Inorganic Biochemistry, Vol. 65, No. 4, 1997, p. 257-262.

Research output: Contribution to journalArticle

Kowalik-Jankowska, T, Várnagy, K, Światek-Kozłowska, J, Jon, A, Sóvágó, I, Sochacka, E, Malkiewicz, A, Spychała, J & Kozłowski, H 1997, 'Role of sulfur site in metal binding to thiopurine and thiopyrimidine nucleosides', Journal of Inorganic Biochemistry, vol. 65, no. 4, pp. 257-262. https://doi.org/10.1016/S0162-0134(96)00140-7
Kowalik-Jankowska, Teresa ; Várnagy, K. ; Światek-Kozłowska, Jolanta ; Jon, Ana ; Sóvágó, I. ; Sochacka, Elzbieta ; Malkiewicz, Andrzej ; Spychała, Jan ; Kozłowski, Henryk. / Role of sulfur site in metal binding to thiopurine and thiopyrimidine nucleosides. In: Journal of Inorganic Biochemistry. 1997 ; Vol. 65, No. 4. pp. 257-262.
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AU - Jon, Ana

AU - Sóvágó, I.

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AU - Spychała, Jan

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