Role of sepsis modulated circulating microRNAs

Bernadett Szilágyi, Zsolt Fejes, Marianna Pócsi, János Kappelmayer, B. Nagy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Sepsis is a life-threating condition with dysregulated systemic host response to microbial pathogens leading to disproportionate inflammatory response and multiorgan failure. Various biomarkers are available for the diagnosis and prognosis of sepsis; however, these laboratory parameters may show limitations in these severe clinical conditions. MicroRNAs (miRNA) are single-stranded non-coding RNAs with the function of post-transcriptional gene silencing. They normally control numerous intracellular events, such as signaling cascade downstream of Toll-like receptors (TLRs) to avoid excessive inflammation after infection. In contrast, abnormal miRNA expression contributes to the development of sepsis correlating with its clinical features and outcomes. Based on recent clinical studies altered levels of circulating miRNAs can act as potential diagnostic and prognostic biomarkers in sepsis. In this review, we summarized the available data about TLR-mediated inflammatory signaling with its intracellular response in immune cells and platelets upon sepsis, which are, at least in part, under the regulation of miRNAs. Furthermore, the role of circulating miRNAs is also described as potential laboratory biomarkers in sepsis.

Original languageEnglish
Pages (from-to)128-145
Number of pages18
JournalElectronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine
Volume30
Issue number2
Publication statusPublished - Jan 1 2019

Keywords

  • Inflammation
  • MicroRNA
  • Monocyte
  • Platelet
  • Sepsis
  • TLR

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Role of sepsis modulated circulating microRNAs'. Together they form a unique fingerprint.

  • Cite this