Role of proteoglycans in tumor progression

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Data is now starting to accumulate on the differential expression of PGs in tumor cells of various invasive/metastatic potential. This is not so surprising if one considers the key functions that PGs play in the regulation of cell proliferation, adhesion and motility. However, characterization of PG expression in individual tumor types still awaits further detailed studies. Data on melanomas clearly indicate that PG phenotype is both specific and also promiscuous in a sense that ectopic expression of certain tissue specific PGs can occur in various tumors. Expression of a metastatic phenotype-specific splice variants of CD44 provides an example for the possible marker-function of PG. This also raises the hope that some PGs could be used as diagnostic/prognostic tools in pathology or even as a therapeutic targets against tumor dissemination. On the other hand, specific glycanation inhibitors may also be used for the modulation of tumor PG exist and the invasive phenotype.

Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalPathology and Oncology Research
Volume1
Issue number1
DOIs
Publication statusPublished - Mar 1995

Fingerprint

Proteoglycans
Neoplasms
Phenotype
Cell Adhesion
Cell Movement
Melanoma
Cell Proliferation
Pathology

Keywords

  • glycosaminoglycan
  • invasion
  • metastasis
  • proteoglycan

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Role of proteoglycans in tumor progression. / Tímár, J.; Jeney, A.; Kovalszky, I.; Kópper, L.

In: Pathology and Oncology Research, Vol. 1, No. 1, 03.1995, p. 85-93.

Research output: Contribution to journalArticle

@article{fd1d482e2c4640d29ba662e61b7b4118,
title = "Role of proteoglycans in tumor progression",
abstract = "Data is now starting to accumulate on the differential expression of PGs in tumor cells of various invasive/metastatic potential. This is not so surprising if one considers the key functions that PGs play in the regulation of cell proliferation, adhesion and motility. However, characterization of PG expression in individual tumor types still awaits further detailed studies. Data on melanomas clearly indicate that PG phenotype is both specific and also promiscuous in a sense that ectopic expression of certain tissue specific PGs can occur in various tumors. Expression of a metastatic phenotype-specific splice variants of CD44 provides an example for the possible marker-function of PG. This also raises the hope that some PGs could be used as diagnostic/prognostic tools in pathology or even as a therapeutic targets against tumor dissemination. On the other hand, specific glycanation inhibitors may also be used for the modulation of tumor PG exist and the invasive phenotype.",
keywords = "glycosaminoglycan, invasion, metastasis, proteoglycan",
author = "J. T{\'i}m{\'a}r and A. Jeney and I. Kovalszky and L. K{\'o}pper",
year = "1995",
month = "3",
doi = "10.1007/BF02893590",
language = "English",
volume = "1",
pages = "85--93",
journal = "Pathology and Oncology Research",
issn = "1219-4956",
publisher = "Springer Netherlands",
number = "1",

}

TY - JOUR

T1 - Role of proteoglycans in tumor progression

AU - Tímár, J.

AU - Jeney, A.

AU - Kovalszky, I.

AU - Kópper, L.

PY - 1995/3

Y1 - 1995/3

N2 - Data is now starting to accumulate on the differential expression of PGs in tumor cells of various invasive/metastatic potential. This is not so surprising if one considers the key functions that PGs play in the regulation of cell proliferation, adhesion and motility. However, characterization of PG expression in individual tumor types still awaits further detailed studies. Data on melanomas clearly indicate that PG phenotype is both specific and also promiscuous in a sense that ectopic expression of certain tissue specific PGs can occur in various tumors. Expression of a metastatic phenotype-specific splice variants of CD44 provides an example for the possible marker-function of PG. This also raises the hope that some PGs could be used as diagnostic/prognostic tools in pathology or even as a therapeutic targets against tumor dissemination. On the other hand, specific glycanation inhibitors may also be used for the modulation of tumor PG exist and the invasive phenotype.

AB - Data is now starting to accumulate on the differential expression of PGs in tumor cells of various invasive/metastatic potential. This is not so surprising if one considers the key functions that PGs play in the regulation of cell proliferation, adhesion and motility. However, characterization of PG expression in individual tumor types still awaits further detailed studies. Data on melanomas clearly indicate that PG phenotype is both specific and also promiscuous in a sense that ectopic expression of certain tissue specific PGs can occur in various tumors. Expression of a metastatic phenotype-specific splice variants of CD44 provides an example for the possible marker-function of PG. This also raises the hope that some PGs could be used as diagnostic/prognostic tools in pathology or even as a therapeutic targets against tumor dissemination. On the other hand, specific glycanation inhibitors may also be used for the modulation of tumor PG exist and the invasive phenotype.

KW - glycosaminoglycan

KW - invasion

KW - metastasis

KW - proteoglycan

UR - http://www.scopus.com/inward/record.url?scp=0002209296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002209296&partnerID=8YFLogxK

U2 - 10.1007/BF02893590

DO - 10.1007/BF02893590

M3 - Article

AN - SCOPUS:0002209296

VL - 1

SP - 85

EP - 93

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

SN - 1219-4956

IS - 1

ER -