Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes.

Original languageEnglish
Pages (from-to)3771-3777
Number of pages7
JournalFEBS letters
Volume586
Issue number21
DOIs
Publication statusPublished - Nov 2 2012

Keywords

  • Adhesion molecule
  • Allergy
  • Chemokine
  • Gene expression
  • Inflammation
  • Nitrosative stress
  • Oxidative stress

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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