Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass

G. Szabó, P. Soós, Susanne Bährle, Zsuzsanna Zsengellér, Christa Flechtenmacher, Siegfried Hagl, Csaba Szabó

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To investigate the effects of PARP inhibition on cardiac and pulmonary function during reperfusion in a clinically relevant experimental model of cardiopulmonary bypass. Methods: Twelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 min of hypothermic cardiac arrest, reperfusion was started after application of either saline vehicle (control, n=6), or the potent PARP-inhibitor PJ34 (5 mg/kg; n=6). Biventricular hemodynamic variables were measured by combined pressure-volume-conductance catheters. Coronary and pulmonary blood flow, vasodilator responses to acetylcholine and sodium-nitroprusside and pulmonary function were also determined. The cardiac and pulmonary activation of PARP was detected by poly(ADP-ribose) immunohistochemistry. Results: Administration of PJ34 led to a significantly better recovery of left and right ventricular systolic function (P

Original languageEnglish
Pages (from-to)825-832
Number of pages8
JournalEuropean Journal of Cardio-thoracic Surgery
Volume25
Issue number5
DOIs
Publication statusPublished - May 2004

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Poly(ADP-ribose) Polymerases
Cardiopulmonary Bypass
Canidae
Lung
Reperfusion
Poly Adenosine Diphosphate Ribose
Right Ventricular Function
Nitroprusside
Heart Arrest
Vasodilator Agents
Acetylcholine
Theoretical Models
Catheters
Hemodynamics
Immunohistochemistry
Dogs
Pressure
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride

Keywords

  • Cardiopulmonary bypass
  • Endothelial function
  • PARP inhibition
  • Reperfusion injury

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass. / Szabó, G.; Soós, P.; Bährle, Susanne; Zsengellér, Zsuzsanna; Flechtenmacher, Christa; Hagl, Siegfried; Szabó, Csaba.

In: European Journal of Cardio-thoracic Surgery, Vol. 25, No. 5, 05.2004, p. 825-832.

Research output: Contribution to journalArticle

Szabó, G. ; Soós, P. ; Bährle, Susanne ; Zsengellér, Zsuzsanna ; Flechtenmacher, Christa ; Hagl, Siegfried ; Szabó, Csaba. / Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass. In: European Journal of Cardio-thoracic Surgery. 2004 ; Vol. 25, No. 5. pp. 825-832.
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