Role of phenothiazines and structurally similar compounds of plant origin in the fight against infections by drug resistant bacteria

Sujata G. Dastidar, Jette E. Kristiansen, J. Molnár, Leonard Amaral

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Phenothiazines have their primary effects on the plasma membranes of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources and energy providing enzymes, such as ATPase, and genes that regulate and code for the permeability aspect of a bacterium. The response of multidrug and extensively drug resistant tuberculosis to phenothiazines shows an alternative therapy for the treatment of these dreaded diseases, which are claiming more and more lives every year throughout the world. Many phenothiazines have shown synergistic activity with several antibiotics thereby lowering the doses of antibiotics administered to patients suffering from specific bacterial infections. Trimeprazine is synergistic with trimethoprim. Flupenthixol (Fp) has been found to be synergistic with penicillin and chlorpromazine (CPZ); in addition, some antibiotics are also synergistic. Along with the antibacterial action described in this review, many phenothiazines possess plasmid curing activities, which render the bacterial carrier of the plasmid sensitive to antibiotics. Thus, simultaneous applications of a phenothiazine like TZ would not only act as an additional antibacterial agent but also would help to eliminate drug resistant plasmid from the infectious bacterial cells.

Original languageEnglish
Pages (from-to)58-72
Number of pages15
JournalAntibiotics
Volume2
Issue number1
DOIs
Publication statusPublished - Feb 18 2013

Fingerprint

Phenothiazines
Bacteria
Anti-Bacterial Agents
Infection
Plasmids
Pharmaceutical Preparations
Cell membranes
Trimeprazine
Extensively Drug-Resistant Tuberculosis
Cell Membrane
Flupenthixol
Trimethoprim
Chlorpromazine
Complementary Therapies
Eukaryota
Bacterial Infections
Penicillins
Adenosine Triphosphatases
Curing
Permeability

Keywords

  • Antimicrobial activities
  • Efflux pumps
  • Phenothiazines
  • Quorum sensing
  • Reversal of antibiotic resistance

ASJC Scopus subject areas

  • Microbiology
  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Role of phenothiazines and structurally similar compounds of plant origin in the fight against infections by drug resistant bacteria. / Dastidar, Sujata G.; Kristiansen, Jette E.; Molnár, J.; Amaral, Leonard.

In: Antibiotics, Vol. 2, No. 1, 18.02.2013, p. 58-72.

Research output: Contribution to journalReview article

Dastidar, Sujata G. ; Kristiansen, Jette E. ; Molnár, J. ; Amaral, Leonard. / Role of phenothiazines and structurally similar compounds of plant origin in the fight against infections by drug resistant bacteria. In: Antibiotics. 2013 ; Vol. 2, No. 1. pp. 58-72.
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