Role of peripheral and brain-derived dopamine (DA) in immune regulation

B. Tóth, M. Vecsernyés, T. Zelles, Kristóf Kádár, György M. Nagy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

There is a well-defined influence of dopamine (DA) within the immune system. It can be synthesized not only in neurons, but also in immune cells, especially in T cells. In addition, these cell are bearing an active uptake mechanism, which could serve another source of DA. Therefore, it is highly likely that a functional DA-erg autocrine/paracrine regulatory loop exists, where lymphocytes-derived DA acting through its own receptors, also expressed on the same cells, can have an influence on its own function. However, the possibility that immune cell derived DA may act in accordance with DA secreted by other sources, i.e. from sympathetic terminals, cannot be ruled out. In harmony with these observations have provided evidences for the existence of a functional DA-erg system in the thymus, indicating that DA may have also a role in the maturation and selection of a certain subpopulation of lymphocytes as well. Based upon all of this information and evidences, for being able to summarize this topic, a much broader survey, including all direct and indirect immune-modulatory role of DA is required. Therefore, in this review we are going to discuss the most relevant aspects of this regulatory function. Facts and theories based upon experimental (pre-clinical) data are extended with the evidences accumulated by clinical observations.

Original languageEnglish
Pages (from-to)111-155
Number of pages45
JournalAdvances in Neuroimmune Biology
Volume3
Issue number2
DOIs
Publication statusPublished - 2012

Fingerprint

Dopamine
Brain
Lymphocyte Subsets
Thymus Gland
Immune System
Lymphocytes
T-Lymphocytes
Neurons

Keywords

  • autocrine/paracrine regulation
  • clinical trial
  • Dopamine
  • immune system
  • lymphocyte
  • lymphokine
  • neurotransmitter

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Endocrinology

Cite this

Role of peripheral and brain-derived dopamine (DA) in immune regulation. / Tóth, B.; Vecsernyés, M.; Zelles, T.; Kádár, Kristóf; Nagy, György M.

In: Advances in Neuroimmune Biology, Vol. 3, No. 2, 2012, p. 111-155.

Research output: Contribution to journalArticle

@article{8821e289b0264ad4943ba1b1406eb812,
title = "Role of peripheral and brain-derived dopamine (DA) in immune regulation",
abstract = "There is a well-defined influence of dopamine (DA) within the immune system. It can be synthesized not only in neurons, but also in immune cells, especially in T cells. In addition, these cell are bearing an active uptake mechanism, which could serve another source of DA. Therefore, it is highly likely that a functional DA-erg autocrine/paracrine regulatory loop exists, where lymphocytes-derived DA acting through its own receptors, also expressed on the same cells, can have an influence on its own function. However, the possibility that immune cell derived DA may act in accordance with DA secreted by other sources, i.e. from sympathetic terminals, cannot be ruled out. In harmony with these observations have provided evidences for the existence of a functional DA-erg system in the thymus, indicating that DA may have also a role in the maturation and selection of a certain subpopulation of lymphocytes as well. Based upon all of this information and evidences, for being able to summarize this topic, a much broader survey, including all direct and indirect immune-modulatory role of DA is required. Therefore, in this review we are going to discuss the most relevant aspects of this regulatory function. Facts and theories based upon experimental (pre-clinical) data are extended with the evidences accumulated by clinical observations.",
keywords = "autocrine/paracrine regulation, clinical trial, Dopamine, immune system, lymphocyte, lymphokine, neurotransmitter",
author = "B. T{\'o}th and M. Vecserny{\'e}s and T. Zelles and Krist{\'o}f K{\'a}d{\'a}r and Nagy, {Gy{\"o}rgy M.}",
year = "2012",
doi = "10.3233/NIB-2012-012044",
language = "English",
volume = "3",
pages = "111--155",
journal = "Advances in Neuroimmune Biology",
issn = "1878-948X",
publisher = "IOS Press",
number = "2",

}

TY - JOUR

T1 - Role of peripheral and brain-derived dopamine (DA) in immune regulation

AU - Tóth, B.

AU - Vecsernyés, M.

AU - Zelles, T.

AU - Kádár, Kristóf

AU - Nagy, György M.

PY - 2012

Y1 - 2012

N2 - There is a well-defined influence of dopamine (DA) within the immune system. It can be synthesized not only in neurons, but also in immune cells, especially in T cells. In addition, these cell are bearing an active uptake mechanism, which could serve another source of DA. Therefore, it is highly likely that a functional DA-erg autocrine/paracrine regulatory loop exists, where lymphocytes-derived DA acting through its own receptors, also expressed on the same cells, can have an influence on its own function. However, the possibility that immune cell derived DA may act in accordance with DA secreted by other sources, i.e. from sympathetic terminals, cannot be ruled out. In harmony with these observations have provided evidences for the existence of a functional DA-erg system in the thymus, indicating that DA may have also a role in the maturation and selection of a certain subpopulation of lymphocytes as well. Based upon all of this information and evidences, for being able to summarize this topic, a much broader survey, including all direct and indirect immune-modulatory role of DA is required. Therefore, in this review we are going to discuss the most relevant aspects of this regulatory function. Facts and theories based upon experimental (pre-clinical) data are extended with the evidences accumulated by clinical observations.

AB - There is a well-defined influence of dopamine (DA) within the immune system. It can be synthesized not only in neurons, but also in immune cells, especially in T cells. In addition, these cell are bearing an active uptake mechanism, which could serve another source of DA. Therefore, it is highly likely that a functional DA-erg autocrine/paracrine regulatory loop exists, where lymphocytes-derived DA acting through its own receptors, also expressed on the same cells, can have an influence on its own function. However, the possibility that immune cell derived DA may act in accordance with DA secreted by other sources, i.e. from sympathetic terminals, cannot be ruled out. In harmony with these observations have provided evidences for the existence of a functional DA-erg system in the thymus, indicating that DA may have also a role in the maturation and selection of a certain subpopulation of lymphocytes as well. Based upon all of this information and evidences, for being able to summarize this topic, a much broader survey, including all direct and indirect immune-modulatory role of DA is required. Therefore, in this review we are going to discuss the most relevant aspects of this regulatory function. Facts and theories based upon experimental (pre-clinical) data are extended with the evidences accumulated by clinical observations.

KW - autocrine/paracrine regulation

KW - clinical trial

KW - Dopamine

KW - immune system

KW - lymphocyte

KW - lymphokine

KW - neurotransmitter

UR - http://www.scopus.com/inward/record.url?scp=84867539666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867539666&partnerID=8YFLogxK

U2 - 10.3233/NIB-2012-012044

DO - 10.3233/NIB-2012-012044

M3 - Article

AN - SCOPUS:84867539666

VL - 3

SP - 111

EP - 155

JO - Advances in Neuroimmune Biology

JF - Advances in Neuroimmune Biology

SN - 1878-948X

IS - 2

ER -