Role of pattern recognition receptors of the neurovascular unit in inflamm-aging

Imola Wilhelm, Nyúl-Tóth, Mihály Kozma, Attila E. Farkas, István A. Krizbai

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Aging is associated with chronic inflammation partly mediated by increased levels of damage-associated molecular patterns, which activate pattern recognition receptors (PRRs) of the innate immune system. Furthermore, many aging-related disorders are associated with inflammation. PRRs, such as Toll-like receptors (TLRs) and nucleotide-binding oligomerization domainlike receptors (NLRs), are expressed not only in cells of the innate immune system but also in other cells, including cells of the neurovascular unit and cerebral vasculature forming the blood-brain barrier. In this review, we summarize our present knowledge about the relationship between activation of PRRs expressed by cells of the neurovascular unit-blood-brain barrier, chronic inflammation, and aging-related pathologies of the brain. The most important damage-associated molecular pattern-sensing PRRs in the brain are TLR2, TLR4, and NLR family pyrin domain-containing protein-1 and pyrin domain-containing protein-3, which are activated during physiological and pathological aging in microglia, neurons, astrocytes, and possibly endothelial cells and pericytes.

Original languageEnglish
Pages (from-to)H1000-H1012
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume313
Issue number5
DOIs
Publication statusPublished - Nov 6 2017

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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