Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders

Lumei Huang, Lilla Otrokocsi, B. Sperlágh

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2X1, 2, 3, 4, 6, and 7, and P2Y 1 , 2 , 6 , 12 , and 13 ) regulate neuronal/neuroglial developmental processes, such as proliferation, differentiation, migration of neuronal precursors, and neurite outgrowth. However, only a few of these subtypes (P2X2, P2X3, P2X4, P2X7, P2Y 1 , and P2Y 2 ) have been investigated in the context of neurodevelopmental psychiatric disorders. The activation of these potential target receptors and their underlying mechanisms mainly influence the process of neuroinflammation. In particular, P2 receptor-mediated inflammatory cytokine release has been indicated to contribute to the complex mechanisms of a variety of CNS disorders. The released inflammatory cytokines could be utilized as biomarkers for neurodevelopmental and psychiatric disorders to improve the early diagnosis intervention, and prognosis. The population changes in gut microbiota after birth are closely linked to neurodevelopmental/neuropsychiatric disorders in later life; thus, the dynamic expression and function of P2 receptors on gut epithelial cells during disease processes indicate a novel avenue for the evaluation of disease progression and for the discovery of related therapeutic compounds.

Original languageEnglish
JournalBrain Research Bulletin
DOIs
Publication statusPublished - Jan 1 2019

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Psychiatry
Central Nervous System Diseases
Brain
Purinergic P2X1 Receptors
Cytokines
Disease Progression
Early Diagnosis
Biomarkers
Epithelial Cells
Parturition
Population
Neurodevelopmental Disorders
Neuronal Outgrowth
Therapeutics
Gastrointestinal Microbiome

Keywords

  • ATP
  • Autism spectrum disorder
  • Development
  • Fetal alcohol spectrum disorder
  • Gut microbiota
  • Neuroinflammation
  • P2 receptors
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders. / Huang, Lumei; Otrokocsi, Lilla; Sperlágh, B.

In: Brain Research Bulletin, 01.01.2019.

Research output: Contribution to journalReview article

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