Az osteopontin szerepe a microcalcificatiók kialakulásában emlócarcinomákban.

Translated title of the contribution: Role of osteopontin in the formation of microcalcifications in breast cancer

A. Tőkés, Judit Krausz, J. Kulka, Márta Jäckel, A. Kádár

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

INTRODUCTION: Osteopontin, a non-collagen, Ca-binding phosphoprotein, plays roles in both physiological and pathological mineralisation processes. Its expression may be severely altered in malignant tumours. AIM: To investigate the presence of this protein in breast tumours showing mammographic microcalcifications. MATERIAL: In this study the authors investigated immunohistochemically the osteopontin expression in 26 breast tumours. The elemental composition of the microcalcifications of the same tumours was also examined with energy dispersive spectrometer linked to a scanning electron microscope. RESULTS: Osteopontin expression was found within the tumours in the tumour cells, in vascular smooth muscle cells, in the myoepithelial cells of the normal ducts, and in macrophages. Extracellular osteopontin positivity was seen around calcified foci. There was no correlation between osteopontin positivity and the examined prognostic factors: grade, type and size of the tumour, axillary lymph nodes status, or age. Two types of microcalcifications were seen: 1. Ca-phosphate only, 2. Those composed of various other elements. CONCLUSION: The presence of osteopontin in the vicinity of calcified foci and in the vessel walls seems to support the hypothesis that osteopontin takes part in calcification process.

Original languageHungarian
Pages (from-to)1841-1846
Number of pages6
JournalOrvosi Hetilap
Volume143
Issue number31
Publication statusPublished - Aug 4 2002

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Calcinosis
Osteopontin
Breast Neoplasms
Neoplasms
Phosphoproteins
Pathologic Processes
Vascular Smooth Muscle
Smooth Muscle Myocytes
Lymph Nodes
Macrophages
Phosphates
Electrons

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az osteopontin szerepe a microcalcificatiók kialakulásában emlócarcinomákban. / Tőkés, A.; Krausz, Judit; Kulka, J.; Jäckel, Márta; Kádár, A.

In: Orvosi Hetilap, Vol. 143, No. 31, 04.08.2002, p. 1841-1846.

Research output: Contribution to journalArticle

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