Role of organ transplantation in the treatment of malignancies - Hepatocellular carcinoma as the most common tumour treated with transplantation

Gyula Végső, Dénes Görög, Imre Fehérvári, Balázs Nemes, Attila Doros, Róbert Miklós Langer, László Kóbori

Research output: Contribution to journalReview article

5 Citations (Scopus)


There are only few malignant tumours where organ transplantation is the treatment of choice. Transplantation can be considered individually in certain lung carcinomas, unresectable heart tumours, cholangiocellular carcinoma and Klatskin tumour. It is acceptable in unresectable chemosensitive hepatoblastoma, epitheloid haemangioendothelioma, liver metastasis of neuroendocrine tumours and as the most common indication, the early hepatocellular carcinoma (HCC) in cirrhotic liver. Results of liver transplantation (LT) for HCC according to Milan criteria as a "gold standard" are excellent. Time of LT has a great influence on the results. While patients are on waiting list, locoregional therapies may help prevent tumour progress. Living donor LT is an acceptable treatment of HCC. The greatest experience with this procedure is in Asia. Despite the favourable results, LT as the treatment of HCC is debated and raises several questions: regarding indication and expectable outcome. Milan criteria seem to answer this questions although they are too strict. The number and size of HCC foci per se is not sufficient predictor of eligibility to transplantation and for prognosis. Majority of the prognostic factors can be evaluated only after transplantation with pathological examination of HCC. Aim of the present research is to find prognostic factors that are characteristic of biological behaviour of HCC, which can be detected before LT in order to select patients who have the greatest benefit from LT. Re-definition of eligibility criteria is an actual question; an international consensus based on additional prospective studies is required for the "new" recommendation.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalPathology and Oncology Research
Issue number1
Publication statusPublished - Jan 2012



  • Bridging therapy
  • Bronchioloalveolar carcinoma
  • Des-gamma-carboxy prothrombin
  • Extended criteria
  • Heart sarcomas
  • Hepatocellular carcinoma
  • Liver transplantation
  • Living donor liver transplantation
  • Milan criteria
  • Proliferation signal inhibitor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this