Role of oligo(malic acid) on the formation of unilamellar vesicles

Attila Bóta, András Wacha, Zoltán Varga, Imola Csilla Szigyártó, Sándor Kristyán, András Lőrincz, Pál Szabó, Miklós Kálmán, Lívia Naszályi-Nagy, Judith Mihály

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Stable unilamellar dipalmitoylphosphatidylcholine vesicles were produced by using oligo(malic acid) and cholesterol. Detailed physico-chemical characterization prove that by using oligo(malic acid) the substitution of PEGylated lipids for sterically stabilization comes possible. The polymer molecules cover the outer surface of spherical-shaped vesicles, and an asymmetrical composition occurs in the two leaflets of the phospholipid bilayer. The oligo(malic-acid) and cholesterol are enriched in the outer side assuring the stabilization of vesicles. Cholesterol plays an important role in the self-assembly of components as it makes the entering of oligomers possible deep into the polar head-region of lipids. The presence of oligo(malic acid) molecules does not induce degradation by hydrolysis of lipid molecules but the vesicle system turns into a sensitive form giving a possibility for pH sensitive targeting. Preliminary investigation on the investigated oligo(malic acid)-stabilized vesicles do not show any toxic effect promising their applicability in the field of liposomal drug delivery.

Original languageEnglish
Pages (from-to)782-789
Number of pages8
JournalJournal of colloid and interface science
Volume532
DOIs
Publication statusPublished - Dec 15 2018

Keywords

  • Freeze fracture
  • Oligo(malic acid)
  • Small-angle X-ray scattering (SAXS)
  • Sterically stabilized vesicle

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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