Role of Nox2 in elimination of microorganisms

Balázs Rada, Csilla Hably, András Meczner, Csaba Timár, Gergely Lakatos, Péter Enyedi, Erzsébet Ligeti

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

NADPH oxidase of the phagocytic cells (Nox2) transfers electrons from cytosolic NADPH to molecular oxygen in the extracellular or intraphagosomal space. The produced superoxide anion (O2.-) provides the source for formation of all toxic oxygen derivatives, but continuous O 2.- generation depends on adequate charge compensation. The vital role of Nox2 in efficient elimination of microorganisms is clearly indicated by human pathology as insufficient activity of the enzyme results in severe, recurrent bacterial infections, the typical symptoms of chronic granulomatous disease. The goals of this contribution are to provide critical review of the Nox2-dependent cellular processes that potentially contribute to bacterial killing and degradation and to indicate possible targets of pharmacological interventions.

Original languageEnglish
Pages (from-to)237-253
Number of pages17
JournalSeminars in Immunopathology
Volume30
Issue number3
DOIs
Publication statusPublished - Jul 1 2008

Keywords

  • Ion movements
  • Killing
  • NADPH oxidase
  • Neutrophilic granulocytes
  • Phagocytes
  • Reactive oxygen species

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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