Role of nonsynaptic communication in regulating the immune response

Zsolt Selmeczy, E. Vízi, Balázs Csóka, Pál Pacher, G. Haskó

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The discovery of nonsynaptic communication in the 1960s and 1970s was an important milestone in investigating the function of the nervous system, and it revolutionized our view about information transmission between neurons. In addition, nonsynaptic communication has a practical importance not only within the nervous system, but in the communication between the peripheral nervous system and other organ systems. Nonsynaptic communication takes place in different immune organs, which are innervated by sympathetic nerve terminals. In addition, the function of microglia, one of the immunocompetent cell types of the brain, can also be affected by neurotransmitters released from axon varicosities. The various functions of immune cells are modulated by released neurotransmitters without any direct synaptic contact between nerve endings and targeted immune cells requiring only functional neurotransmitter receptors on immune cells. Here, we briefly overview the role of the various receptor subtypes mediating nonsynaptic modulation of the function of immunocompetent cells both in the periphery and in the central nervous system.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalNeurochemistry International
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Nervous System
Neurotransmitter Agents
Neurotransmitter Receptor
Nerve Endings
Peripheral Nervous System
Microglia
Axons
Central Nervous System
Neurons
Brain

Keywords

  • Adenosine receptors
  • Adrenergic receptors
  • Immune cells
  • Microglia
  • Nonsynaptic communication

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Role of nonsynaptic communication in regulating the immune response. / Selmeczy, Zsolt; Vízi, E.; Csóka, Balázs; Pacher, Pál; Haskó, G.

In: Neurochemistry International, Vol. 52, No. 1, 01.2008, p. 52-59.

Research output: Contribution to journalArticle

Selmeczy, Zsolt ; Vízi, E. ; Csóka, Balázs ; Pacher, Pál ; Haskó, G. / Role of nonsynaptic communication in regulating the immune response. In: Neurochemistry International. 2008 ; Vol. 52, No. 1. pp. 52-59.
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