Role of nitric oxide in the gastric cytoprotection induced by central vagal stimulation

Ágnes Király, Gábor Sütő, Yvette Taché

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The role of nitric oxide (NO) in the vagal cholinergic-mediated cytoprotective effect of intracisternal (i.c.) injection of the stable thyrotropin-releasing hormone (TRH) analog, RX 77368, was investigated in conscious rats. RX 77368 (1.5 ng i.c.) reduced by 88% gastric hemorrhagic lesions induced by oral administration of ethanol (60%). L-N G -Nitro-arginine methyl ester (L-NAME, 3 mg/kg i.v.), an inhibitor of NO synthase, abolished the cytoprotection provided by i.c. RX 77368. The effect of L-NAME was reversed by L- but not D-arginine. These results suggest that the L-arginine-nitric oxide pathway is involved in the cytoprotective effect of i.c. TRH analog, probably through the modulation of gastric mucosal blood flow.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalEuropean Journal of Pharmacology
Volume240
Issue number2-3
DOIs
Publication statusPublished - Aug 24 1993

Keywords

  • Gastric cytoprotection
  • L-Arginine
  • L-NAME (N -nitro-L-arginine methyl ester)
  • Nitric oxide (NO)
  • RX 77368
  • Vagus

ASJC Scopus subject areas

  • Pharmacology

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