Role of nitric oxide in regulating cerebrocortical oxygen consumption and blood flow during hypercapnia

I. Horváth, Norbert T. Sandor, Zoltan Ruttner, Alan C. McLaughlin

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The effect of the nitric oxide (NO) synthase inhibitor N(ω)-nitro-L- arginine methyl ester (L-NAME) on the response of cerebrocortical oxygen consumption (CMRO2) and blood flow (CBF) to two levels of hypercapnia (P(a)CO2 ~ 60 mm Hg and P(a)CO2 ~ 90 mm Hg) was investigated in ketamine- anesthetized rats. CBF was calculated using the Kety-Schmidt approach and CMRO2 was calculated from the product of CBF and the arteriovenous (superior sagittal sinus) difference for oxygen. L-NAME treatment did not have a significant effect on either CMRO2 or CBF under normocapnic conditions but inhibited the hypercapnic increase of CMRO2 and the hypercapnic increase in CBF. These results suggest that NO plays a role in the response of CMRO2 and CBF during hypercapnia and are consistent with the suggestion that at least part of the increase in CBF observed during hypercapnia is coupled to an increase in CMRO2.

Original languageEnglish
Pages (from-to)503-509
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume14
Issue number3
Publication statusPublished - May 1994

Fingerprint

Hypercapnia
Oxygen Consumption
Nitric Oxide
NG-Nitroarginine Methyl Ester
Superior Sagittal Sinus
Ketamine
Nitric Oxide Synthase
Oxygen

Keywords

  • Cerebral blood flow
  • Cerebral oxygen consumption
  • Hypercapnia
  • L-NAME
  • Nitric oxide

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

Cite this

Role of nitric oxide in regulating cerebrocortical oxygen consumption and blood flow during hypercapnia. / Horváth, I.; Sandor, Norbert T.; Ruttner, Zoltan; McLaughlin, Alan C.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 14, No. 3, 05.1994, p. 503-509.

Research output: Contribution to journalArticle

Horváth, I. ; Sandor, Norbert T. ; Ruttner, Zoltan ; McLaughlin, Alan C. / Role of nitric oxide in regulating cerebrocortical oxygen consumption and blood flow during hypercapnia. In: Journal of Cerebral Blood Flow and Metabolism. 1994 ; Vol. 14, No. 3. pp. 503-509.
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