Role of nitric oxide in physiology and patophysiology of periodontal tissues

Z. M. Lohinai, C. Szabo

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

The purpose of our review the role of nitric oxide (NO) in periodontal tissues in physiological and pathophysiological conditions. NO is produced by three isoforms of NO synthase (NOS): the constitutive, endothelial isoform, eNOS; the constitutive neuronal isoform, bNOS; and the inducible isoform, iNOS. All three isoforms are present or can be expressed in periodontal tissues. ENOS is located in the vascular endothelium, bNOS in the perivascular and soliter nerve fibers. The constitutive isoforms are present under normal (physiological) conditions. NO produced physiologically by eNOS is protective in circumdental tissues, promotes perfusion and may exert anti- inflammatory effects. The expression of iNOS is induced in inflammatory conditions, such as periodontitis. NO produced by iNOS, or peroxynitrite, its reaction product are detrimental when produced in excess in inflammation. The purpose of iNOS expression in periodontitis is presumably to produce NO and destroy the invading microorganisms. However, iNOS-derived NO or peroxynitrite may destroy the host tissues as well. Selective inhibition of iNOS may be of therapeutic utility in periodontitis.

Original languageEnglish
Pages (from-to)1089-1095
Number of pages7
JournalMedical Science Monitor
Volume4
Issue number6
Publication statusPublished - Dec 1 1998

Keywords

  • Nitric oxide
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Medicine(all)

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