A tiszta progeszteronkészítmények alkalmazása a sterilitás és infertilitás kezelésében

Translated title of the contribution: Role of natural progesterone in the treatment of sterility and infertility

J. Urbancsek, E. Hauzman

Research output: Contribution to journalArticle

Abstract

Progesterone produced by luteinized granulosa cells has a pivotal role in the female menstrual cycle and in the establishment and maintenance of pregnancy in its early phases. Thus, dysfunctional progesterone production not only results in abnormal menstrual cycles but can also lead to sterility and infertility. This paper gives a review on the role of different progestogens and natural progesterone in the treatment of luteal phase deficiency and imminent and habitual abortion, and also deals with the widespread use of progesterone in in vitro fertilization treatment protocols (combined GnRH-agonist or antagonist and hMG stimulation; oocyte donation). Based on the pharmacokinetics of natural progesterone, the article gives detailed information on the efficacy of different routes of administration. Despite controversy between studies published on the efficacy of natural progesterone in the treatment of luteal phase deficiency leading to sterility and treatment of imminent or habitual abortion, administration of natural progesterone is superior to the use of synthetic progestogens or hCG, as synthetic progestogens affect lipid and carbohydrate metabolism, and the use of hCG may result in enlargement of corpus luteum cysts often seen in early pregnancy and may also lead to hyperstimulation syndrome.

Original languageHungarian
Pages (from-to)127-135
Number of pages9
JournalMagyar Noorvosok Lapja
Volume64
Issue number2
Publication statusPublished - 2001

Fingerprint

Infertility
Progesterone
Progesterone Congeners
Habitual Abortion
Luteal Phase
Menstrual Cycle
Therapeutics
Oocyte Donation
Pregnancy Maintenance
Ovarian Cysts
Granulosa Cells
Carbohydrate Metabolism
Progestins
Fertilization in Vitro
Clinical Protocols
Lipid Metabolism
Gonadotropin-Releasing Hormone
Pharmacokinetics
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

A tiszta progeszteronkészítmények alkalmazása a sterilitás és infertilitás kezelésében. / Urbancsek, J.; Hauzman, E.

In: Magyar Noorvosok Lapja, Vol. 64, No. 2, 2001, p. 127-135.

Research output: Contribution to journalArticle

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