Progesterone produced by luteinized granulosa cells has a pivotal role in the female menstrual cycle and in the establishment and maintenance of pregnancy in its early phases. Thus, dysfunctional progesterone production not only results in abnormal menstrual cycles but can also lead to sterility and infertility. This paper gives a review on the role of different progestogens and natural progesterone in the treatment of luteal phase deficiency and imminent and habitual abortion, and also deals with the widespread use of progesterone in in vitro fertilization treatment protocols (combined GnRH-agonist or antagonist and hMG stimulation; oocyte donation). Based on the pharmacokinetics of natural progesterone, the article gives detailed information on the efficacy of different routes of administration. Despite controversy between studies published on the efficacy of natural progesterone in the treatment of luteal phase deficiency leading to sterility and treatment of imminent or habitual abortion, administration of natural progesterone is superior to the use of synthetic progestogens or hCG, as synthetic progestogens affect lipid and carbohydrate metabolism, and the use of hCG may result in enlargement of corpus luteum cysts often seen in early pregnancy and may also lead to hyperstimulation syndrome.
|Number of pages||9|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2001|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology