Role of MicroRNAs in NAFLD/NASH

G. Szabó, Timea Csak

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are highly conserved, small, 18–25 nucleotide, non-coding RNAs that regulate gene expression at the post-transcriptional level. Each miRNA can regulate hundreds of target genes, and vice versa each target gene can be regulated by numerous miRNAs, suggesting a very complex network and explaining how miRNAs play pivotal roles in fine-tuning essentially all biological processes in all cell types in the liver. Here, we summarize the current knowledge on the role of miRNAs in the pathogenesis and diagnosis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) with an outlook to the broader aspects of metabolic syndrome. Furthermore, we discuss the role of miRNAs as potential biomarkers and therapeutic targets in NAFLD/NASH.

Original languageEnglish
Pages (from-to)1314-1324
Number of pages11
JournalDigestive Diseases and Sciences
Volume61
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

MicroRNAs
Biological Phenomena
Untranslated RNA
Genes
Non-alcoholic Fatty Liver Disease
Nucleotides
Biomarkers
Gene Expression
Liver

Keywords

  • MicroRNAs
  • NAFLD
  • NASH

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Role of MicroRNAs in NAFLD/NASH. / Szabó, G.; Csak, Timea.

In: Digestive Diseases and Sciences, Vol. 61, No. 5, 01.05.2016, p. 1314-1324.

Research output: Contribution to journalReview article

Szabó, G. ; Csak, Timea. / Role of MicroRNAs in NAFLD/NASH. In: Digestive Diseases and Sciences. 2016 ; Vol. 61, No. 5. pp. 1314-1324.
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