Role of lnterleukin-8 receptor in skin

L. Kemény, Thomas Rózicka, A. Dobozy, Günter Michel

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Interleukin-8 (IL-8) is a potent chemotactic and proinflammatory cytokine, produced in the skin by a variety of cells in response to inflammatory stimuli. Recent studies suggest that in addition to its potent actions on leukocytes, IL-8 exerts a direct influence on several functions of human epidermal cells such as chemo- taxis, Candida albicans killing activity or proliferation. The effects of IL-8 are mediated by binding to two types of specific high-affinity receptors which contain seven transmembrane domains typical of guanine nucleotide binding protein (G protein)-coupled receptors. In the skin, a broad spectrum of cells such as neutrophils, T lymphocytes, mast cells, dermal macrophages, endothelial cells and keratinocytes possess binding sites for IL-8. Recently, increased expression of epidermal IL-8 receptors has been observed in psoriasis an inflammatory and hyperproliferative skin disease. Since the effects of IL-8 may be modulated at the receptor level, the pharmacological manipulation of the IL-8 receptor may prove an important target for the therapy of skin diseases with increased IL-8 levels.

Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume104
Issue number4
DOIs
Publication statusPublished - 1994

Fingerprint

Interleukin-8
Skin
Interleukin-8 Receptors
Skin Diseases
Guanine Nucleotides
G-Protein-Coupled Receptors
Candida albicans
Keratinocytes
Chemokines
Psoriasis
Mast Cells
Carrier Proteins
Neutrophils
Leukocytes
Endothelial Cells
Macrophages
Binding Sites
Pharmacology
T-Lymphocytes

Keywords

  • Interleukin-8
  • Interleukin-8 receptor
  • Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Role of lnterleukin-8 receptor in skin. / Kemény, L.; Rózicka, Thomas; Dobozy, A.; Michel, Günter.

In: International Archives of Allergy and Immunology, Vol. 104, No. 4, 1994, p. 317-322.

Research output: Contribution to journalArticle

Kemény, L. ; Rózicka, Thomas ; Dobozy, A. ; Michel, Günter. / Role of lnterleukin-8 receptor in skin. In: International Archives of Allergy and Immunology. 1994 ; Vol. 104, No. 4. pp. 317-322.
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