Role of intraamygdaloid acylated-ghrelin in spatial learning

Krisztián Tóth, Kristóf László, László Lénárd

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

According to recently published papers acylated-ghrelin (A-Ghr) modifies memory and learning. The basolateral nucleus of amygdala (ABL) participates in the regulation of memory and learning mechanisms. Previously we verified A-Ghr responsive neurons in the ABL by electrophysiological methods. In male Wistar rats effects of bilateral intraamygdaloid microinfusion of 50 ng, 100 ng A-Ghr, 15 ng Ghr receptor antagonist d-Lys3-GHRP-6 (ANT) or ANT + 50 ng A-Ghr [dissolved in 0.15 M sterile saline], or vehicle in 0.4 μl volume were investigated in Morris water maze paradigm. 50 ng A-Ghr significantly reduced latency to find the platform located in one of the quadrants of the maze. Effect of 50 ng A-Ghr was blocked by ANT pretreatment. ANT alone had no effect. Our results show that place learning linked memory processes are facilitated by A-Ghr in the rat ABL. It is a specific effect, because it could be eliminated by ANT pretreatment.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalBrain Research Bulletin
Volume81
Issue number1
DOIs
Publication statusPublished - Jan 15 2010

Keywords

  • Amygdaloid body
  • Ghrelin
  • Memory
  • Morris water maze

ASJC Scopus subject areas

  • Neuroscience(all)

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