Role of hsa-miR-325 in the etiopathology of preeclampsia

Levente Lázár, B. Nagy, A. Molvarec, András Szarka, J. Rigó

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Preeclampsia (PE) is a common pregnancy-specific syndrome characterized by hypertension and proteinuria. Evidence has demonstrated that hypertensive disorders in pregnancy are associated with alterations in the expression of different microRNAs (miRNAs). miRNAs are endogenously expressed non-coding RNAs that have significant biological and pathological functions due to their potential mechanisms of regulation of gene expression. The purpose of the present study was to investigate the expression of hsa-miR-325 in placental samples of preeclamptic and uncomplicated pregnancy patients. hsa-miR-325 was isolated from placenta tissue samples obtained from 31 preeclamptic and 28 normotensive pregnant females. Quantitative real-time polymerase chain reaction was used to analyze miRNA expression. The expression of hsa-miR-325 was elevated in uncomplicated pregnancies compared with preeclamptic patients. ΔCt (mean ± SD) values were 0.117±0.07 in PE tissues and 0.135±0.051 in normotensive cases (p

Original languageEnglish
Pages (from-to)597-600
Number of pages4
JournalMolecular Medicine Reports
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Pre-Eclampsia
MicroRNAs
Pregnancy
Tissue
Untranslated RNA
Polymerase chain reaction
Gene expression
Gene Expression Regulation
Proteinuria
Placenta
Real-Time Polymerase Chain Reaction
Hypertension
human MIRN325 microRNA

Keywords

  • hsa-miR-325
  • Preeclampsia
  • Real-time PCR

ASJC Scopus subject areas

  • Biochemistry
  • Cancer Research
  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Oncology

Cite this

Role of hsa-miR-325 in the etiopathology of preeclampsia. / Lázár, Levente; Nagy, B.; Molvarec, A.; Szarka, András; Rigó, J.

In: Molecular Medicine Reports, Vol. 6, No. 3, 09.2012, p. 597-600.

Research output: Contribution to journalArticle

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