Role of histamine in the development of neurogenic inflammation of rat oral mucosa

A. Györfi, A. Fazekas, E. Pósch, F. Irmes, L. Rosivall

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The mechanism of development of neurogenic inflammatory reaction induced by the topical application of capsaicin was studied in the oral mucosa of rats with or without histamine antagonist pretreatment. The existence of a cholinergic component of the vasodilation was investigated using a muscarinic receptor antagonist. Results indicated that the neurogenic inflammatory increases in vascular permeability and blood flow are mediated in part by H1-receptors. H2-receptors and cholinergic pathways are apparently not activated in these processes.

Original languageEnglish
Pages (from-to)229-236
Number of pages8
JournalAgents and Actions
Volume32
Issue number3-4
DOIs
Publication statusPublished - Mar 1 1991

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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