Role of GABA and Glu plasma membrane transporters in the interplay of inhibitory and excitatory neurotransmission

László Héja, Kinga Karacs, J. Kardos

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Neurotransmitter plasma membrane transporters do have much more to perform than simply terminating synaptic transmission and replenishing neurotransmitter pools. Findings in the past decade have evidenced their function in maintaining physiological synaptic excitability, and their actions in critical or pathological conditions, also. Conclusively these findings indicated a previously unrecognized role for neurotransmitter plasma membrane transporters in both, synaptic and nonsynaptic signaling. Major inhibitory and excitatory neurotransmitters within the brain, GABA and Glu, have long been considered to operate through independent systems (GABAergic or Gluergic), each of them characterized by its own localization, function and dedicated GABAergic or Gluergic cell phenotypes. Recent advances, however, have challenged this long-standing paradigm. Localization of GABA in Gluergic terminals and Glu in GABAergic cells were reported. Specific plasma membrane transporters for GABA and Glu are also co-localized in different brain areas. Although, their role in regulating each other's signal is still far from being understood, emerging lines of evidence on interplaying GABAergic and Gluergic processes through plasma membrane transporters opens up a new avenue in the field of more specific therapeutic intervention.

Original languageEnglish
Pages (from-to)989-995
Number of pages7
JournalCurrent Topics in Medicinal Chemistry
Volume6
Issue number10
DOIs
Publication statusPublished - May 2006

Fingerprint

Plasma Membrane Neurotransmitter Transport Proteins
Membrane Transport Proteins
Cell membranes
Synaptic Transmission
Neurotransmitter Agents
Brain
Cell Membrane
gamma-Aminobutyric Acid
Phenotype
N-(gamma-aminobutyryl)glutamic acid
Therapeutics

Keywords

  • Amino acid ergot derivatives
  • Localization of GABA and Glu transporters
  • Nonsynaptic signaling
  • Reversed mode of transport
  • Surface expression
  • Zn ion

ASJC Scopus subject areas

  • Medicine(all)
  • Chemistry(all)

Cite this

Role of GABA and Glu plasma membrane transporters in the interplay of inhibitory and excitatory neurotransmission. / Héja, László; Karacs, Kinga; Kardos, J.

In: Current Topics in Medicinal Chemistry, Vol. 6, No. 10, 05.2006, p. 989-995.

Research output: Contribution to journalArticle

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