Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis

Miklos Tunyogi-Csapo, Tamas Koreny, C. Vermes, Jorge O. Galante, Joshua J. Jacobs, Tibor T. Glant

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The periprosthetic granulomatous soft tissue [designated iterfacial membrane (IFM) in this study] exhibits heterogeneous histopathological features, in which highly vascularized areas with dense cellularity alternate with fibrotic and pseudocapsule-like tissue structures. Although macrophage/monocyte activation is a prominent event in the periprosthetic environment, fibroblasts also phagocytose particulate wear debris both in vivo and in vitro. Particulate wear debris and/or cytokines/growth factors alone or in combination (e.g., in conditioned media of explant cultures of IFMs) stimulated normal synovial and IFM fibroblasts to express inflammatory mediators and growth factors such as interleukin (IL)-1β, IL-6, IL-8, three isoforms of vascular endothelial growth factor (VEGF), monocyte/macrophage chemoattractant protein-1 (MCP-1), macrophage-colony-stimulating factor (M-CSF), cycloxygenases (Cox-1 and Cox-2), acid- and basic-fibroblast growth factors (FGF-1 and FGF-2), leukemia inhibitory factor-1 (LIF-1), transforming growth factor β-1 (TGF-β1), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG). Thus, the fibroblast is capable of expressing a wide array of angiogenic and osteoclastogenic factors which are involved in the detrimental processes of the periprosthetic osteolysis.

Original languageEnglish
Pages (from-to)1378-1388
Number of pages11
JournalJournal of Orthopaedic Research
Volume25
Issue number10
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Fibroblast Growth Factors
Fibroblast Growth Factor 1
Fibroblasts
Fibroblast Growth Factor 2
Intercellular Signaling Peptides and Proteins
RANK Ligand
Leukemia Inhibitory Factor
Osteoprotegerin
Osteolysis
Macrophage Colony-Stimulating Factor
Growth Factor Receptors
Macrophage Activation
Synovial Membrane
Chemokine CCL2
Angiogenesis Inducing Agents
Transforming Growth Factors
Conditioned Culture Medium
Interleukin-8
Interleukin-1
Phagocytosis

Keywords

  • Chemokines
  • Fibroblast
  • Periprosthetic osteolysis
  • Proinflammatory cytokines
  • Wear debris

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis. / Tunyogi-Csapo, Miklos; Koreny, Tamas; Vermes, C.; Galante, Jorge O.; Jacobs, Joshua J.; Glant, Tibor T.

In: Journal of Orthopaedic Research, Vol. 25, No. 10, 10.2007, p. 1378-1388.

Research output: Contribution to journalArticle

Tunyogi-Csapo, M, Koreny, T, Vermes, C, Galante, JO, Jacobs, JJ & Glant, TT 2007, 'Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis', Journal of Orthopaedic Research, vol. 25, no. 10, pp. 1378-1388. https://doi.org/10.1002/jor.20449
Tunyogi-Csapo, Miklos ; Koreny, Tamas ; Vermes, C. ; Galante, Jorge O. ; Jacobs, Joshua J. ; Glant, Tibor T. / Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis. In: Journal of Orthopaedic Research. 2007 ; Vol. 25, No. 10. pp. 1378-1388.
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