Az eritropoetin szerepe az idegrendszer fejlodésében, muködésében és a neuroprotekcióban

Translated title of the contribution: Role of erythropoietin in brain homeostasis, neurodevelopment and neuroprotection

István Kocsis, András Treszl, B. Vásárhelyi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Erythropoietin is known as a cytokine regulating the erythrocyte production. Based on recent research it became clear that it is secreted not only by the kidney, but by the central nervous system as well, and erythropoietin receptors are present there, too. Animal and human studies found that the expression of erythropoietin and its receptor is changing through neurodevelopment, which has impact on the differentiation of neuronal cells and is essential for normal neurodevelopment. In addition erythropoietin is protective against several mechanisms of neuronal injury: it alleviates the outcome of hypoxia and glutamate toxicity and has antiapoptotic effects. Based on these results the neuroprotective effects of exogenously administered erythropoietin was studied in several clinical studies. The available data indicate that erythropoietin or its analogues may have a role in neuroprotection in clinical settings.

Original languageHungarian
Pages (from-to)2527-2532
Number of pages6
JournalOrvosi Hetilap
Volume146
Issue number50
Publication statusPublished - 2005

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Erythropoietin
Homeostasis
Erythropoietin Receptors
Brain
Neuroprotective Agents
Cell Differentiation
Glutamic Acid
Central Nervous System
Erythrocytes
Cytokines
Kidney
Neuroprotection
Wounds and Injuries
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az eritropoetin szerepe az idegrendszer fejlodésében, muködésében és a neuroprotekcióban. / Kocsis, István; Treszl, András; Vásárhelyi, B.

In: Orvosi Hetilap, Vol. 146, No. 50, 2005, p. 2527-2532.

Research output: Contribution to journalArticle

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