Role of epigenetics in EBV regulation and pathogenesis

Hans Helmut Niller, Zsófia Tarnai, Gábor Decsi, Ádám Zsedényi, Ferenc Bánáti, J. Mináróvits

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Epigenetic modifications of the viral and host cell genomes regularly occur in EBV-associated lymphomas and carcinomas. The cell type-dependent usage of latent EBV promoters is determined by the cellular epigenetic machinery. Viral oncoproteins interact with the very same epigenetic regulators and alter the cellular epigenotype and gene-expression pattern: there are common gene sets hypermethylated in both EBV-positive and EBV-negative neoplasms of different histological types. A group of hypermethylated promoters may represent, however, a unique EBV-associated epigenetic signature in EBV-positive gastric carcinomas. By contrast, EBV-immortalized B-lymphoblastoid cell lines are characterized by genome-wide demethylation and loss and rearrangement of heterochromatic histone marks. Early steps of EBV infection may also contribute to reprogramming of the cellular epigenome.

Original languageEnglish
Pages (from-to)747-756
Number of pages10
JournalFuture Microbiology
Volume9
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

Human Herpesvirus 4
Epigenomics
Neoplasms by Histologic Type
Histone Code
Genome
Carcinoma
Epstein-Barr Virus Infections
Oncogene Proteins
Lymphoma
Stomach
Gene Expression
Cell Line
Genes

Keywords

  • CpG island
  • DNA methylation
  • epigenetic regulation
  • histone modification
  • hit and run oncogenesis
  • methylome
  • pioneer transcription factor
  • Polycomb repressor complex
  • tumor suppressor

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Medicine(all)

Cite this

Niller, H. H., Tarnai, Z., Decsi, G., Zsedényi, Á., Bánáti, F., & Mináróvits, J. (2014). Role of epigenetics in EBV regulation and pathogenesis. Future Microbiology, 9(6), 747-756. https://doi.org/10.2217/fmb.14.41

Role of epigenetics in EBV regulation and pathogenesis. / Niller, Hans Helmut; Tarnai, Zsófia; Decsi, Gábor; Zsedényi, Ádám; Bánáti, Ferenc; Mináróvits, J.

In: Future Microbiology, Vol. 9, No. 6, 2014, p. 747-756.

Research output: Contribution to journalArticle

Niller, HH, Tarnai, Z, Decsi, G, Zsedényi, Á, Bánáti, F & Mináróvits, J 2014, 'Role of epigenetics in EBV regulation and pathogenesis', Future Microbiology, vol. 9, no. 6, pp. 747-756. https://doi.org/10.2217/fmb.14.41
Niller, Hans Helmut ; Tarnai, Zsófia ; Decsi, Gábor ; Zsedényi, Ádám ; Bánáti, Ferenc ; Mináróvits, J. / Role of epigenetics in EBV regulation and pathogenesis. In: Future Microbiology. 2014 ; Vol. 9, No. 6. pp. 747-756.
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