Az endogén kannabinoid rendszer szerepe az agyi jutalmazó (reward) rendszerekben.

Translated title of the contribution: Role of endogenous cannabinoids in cerebral reward mechanisms

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Central cannabinoid receptors (CB1 receptors) are densely located in the output nuclei of the basal ganglia (globus pallidus, substantia nigra pars reticulata). Endogenous cannabinoids appear to modulate transmitter systems (e.g. dopamine) within the basal ganglia. In the striatum, CB1 receptors are localized on the same neurons as Gi-coupled dopamine D2 receptors. Striatal CB1 receptors are also negatively linked to adenylcyase, and may modulate dopamine release. The presence of CB1 receptors in dopaminergic neurons strongly suggests that cannabinoids play a modulatory role in dopaminergic neuronal pathways. This co-localization may postulate "cross talk" between endocannabinoids and dopamine-dependent reward mechanisms.

Original languageHungarian
Pages (from-to)26-29
Number of pages4
JournalNeuropsychopharmacologia Hungarica
Volume6
Issue number1
Publication statusPublished - 2004

Fingerprint

Cannabinoid Receptor CB1
Cannabinoids
Reward
Dopamine
Basal Ganglia
Corpus Striatum
Endocannabinoids
Globus Pallidus
Dopamine D2 Receptors
Dopaminergic Neurons
Neurons

Cite this

@article{e6279be459da4293a936969fa13b7460,
title = "Az endog{\'e}n kannabinoid rendszer szerepe az agyi jutalmaz{\'o} (reward) rendszerekben.",
abstract = "Central cannabinoid receptors (CB1 receptors) are densely located in the output nuclei of the basal ganglia (globus pallidus, substantia nigra pars reticulata). Endogenous cannabinoids appear to modulate transmitter systems (e.g. dopamine) within the basal ganglia. In the striatum, CB1 receptors are localized on the same neurons as Gi-coupled dopamine D2 receptors. Striatal CB1 receptors are also negatively linked to adenylcyase, and may modulate dopamine release. The presence of CB1 receptors in dopaminergic neurons strongly suggests that cannabinoids play a modulatory role in dopaminergic neuronal pathways. This co-localization may postulate {"}cross talk{"} between endocannabinoids and dopamine-dependent reward mechanisms.",
author = "T. Wenger and S. F{\"u}rst",
year = "2004",
language = "Hungarian",
volume = "6",
pages = "26--29",
journal = "Neuropsychopharmacologia Hungarica",
issn = "1419-8711",
publisher = "Hungarian Association of Psychopharmacology",
number = "1",

}

TY - JOUR

T1 - Az endogén kannabinoid rendszer szerepe az agyi jutalmazó (reward) rendszerekben.

AU - Wenger, T.

AU - Fürst, S.

PY - 2004

Y1 - 2004

N2 - Central cannabinoid receptors (CB1 receptors) are densely located in the output nuclei of the basal ganglia (globus pallidus, substantia nigra pars reticulata). Endogenous cannabinoids appear to modulate transmitter systems (e.g. dopamine) within the basal ganglia. In the striatum, CB1 receptors are localized on the same neurons as Gi-coupled dopamine D2 receptors. Striatal CB1 receptors are also negatively linked to adenylcyase, and may modulate dopamine release. The presence of CB1 receptors in dopaminergic neurons strongly suggests that cannabinoids play a modulatory role in dopaminergic neuronal pathways. This co-localization may postulate "cross talk" between endocannabinoids and dopamine-dependent reward mechanisms.

AB - Central cannabinoid receptors (CB1 receptors) are densely located in the output nuclei of the basal ganglia (globus pallidus, substantia nigra pars reticulata). Endogenous cannabinoids appear to modulate transmitter systems (e.g. dopamine) within the basal ganglia. In the striatum, CB1 receptors are localized on the same neurons as Gi-coupled dopamine D2 receptors. Striatal CB1 receptors are also negatively linked to adenylcyase, and may modulate dopamine release. The presence of CB1 receptors in dopaminergic neurons strongly suggests that cannabinoids play a modulatory role in dopaminergic neuronal pathways. This co-localization may postulate "cross talk" between endocannabinoids and dopamine-dependent reward mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=2942648514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942648514&partnerID=8YFLogxK

M3 - Article

C2 - 15125311

AN - SCOPUS:2942648514

VL - 6

SP - 26

EP - 29

JO - Neuropsychopharmacologia Hungarica

JF - Neuropsychopharmacologia Hungarica

SN - 1419-8711

IS - 1

ER -