Role of D1 dopamine receptors of the ventral pallidum in inhibitory avoidance learning

László Péczely, Tamás Ollmann, Kristóf László, Anita Kovács, Rita Gálosi, Ádám Szabó, Zoltán Karádi, L. Lénárd

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The mesolimbic dopaminergic system (MLDS) originating from the ventral tegmental area has important role in the regulation of motivation, learning and memory. The ventral pallidum (VP), innervated by the MLDS, is involved in the regulation of adaptive behavior, but its exact role is not known in inhibitory avoidance learning. The VP contains both D1 and D2 dopamine receptors, but the density of the former subtype is more excessive. Therefore, in our present experiments, the role of D1 dopamine receptors of the VP in one trial step-through inhibitory avoidance paradigm was investigated.In the conditioning trial, animals were shocked 3 times with 0.5. mA current for 1. s, and subsequently were microinjected bilaterally with D1 dopamine receptor agonist SKF38393 into the VP in three doses (0.1. μg, 1.0. μg or 5.0. μg in 0.4. μl saline). To clarify whether the agonist effect was specific, we also applied the D1 dopamine receptor antagonist SCH23390 (5.0. μg in 0.4. μl saline) 15. min prior the agonist treatment.The D1 dopamine receptor agonist, in a dose-dependent manner, significantly increased the step-through latency during the test trials: retention was significant relative to the controls even after 2 weeks of conditioning. The D1 dopamine receptor antagonist SCH23390 pretreatment eliminated SKF38393 effects in the ventral pallidum. Our results show that D1 dopamine receptor mediated mechanisms in the VP facilitate learning and memory in inhibitory avoidance paradigm and this facilitation is specific because it can be eliminated by D1 dopamine receptor antagonist.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalBehavioural Brain Research
Volume270
DOIs
Publication statusPublished - Aug 15 2014

Fingerprint

Avoidance Learning
Dopamine D1 Receptors
Dopamine Antagonists
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Dopamine Agonists
Learning
Ventral Tegmental Area
Dopamine D2 Receptors
Psychological Adaptation
Basal Forebrain
Motivation

Keywords

  • D1 dopamine receptors
  • Inhibitory avoidance learning
  • Memory consolidation
  • SCH23390
  • SKF38393
  • Ventral pallidum

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Medicine(all)

Cite this

Role of D1 dopamine receptors of the ventral pallidum in inhibitory avoidance learning. / Péczely, László; Ollmann, Tamás; László, Kristóf; Kovács, Anita; Gálosi, Rita; Szabó, Ádám; Karádi, Zoltán; Lénárd, L.

In: Behavioural Brain Research, Vol. 270, 15.08.2014, p. 131-136.

Research output: Contribution to journalArticle

Péczely, L, Ollmann, T, László, K, Kovács, A, Gálosi, R, Szabó, Á, Karádi, Z & Lénárd, L 2014, 'Role of D1 dopamine receptors of the ventral pallidum in inhibitory avoidance learning', Behavioural Brain Research, vol. 270, pp. 131-136. https://doi.org/10.1016/j.bbr.2014.04.054
Péczely L, Ollmann T, László K, Kovács A, Gálosi R, Szabó Á et al. Role of D1 dopamine receptors of the ventral pallidum in inhibitory avoidance learning. Behavioural Brain Research. 2014 Aug 15;270:131-136. https://doi.org/10.1016/j.bbr.2014.04.054
Péczely, László ; Ollmann, Tamás ; László, Kristóf ; Kovács, Anita ; Gálosi, Rita ; Szabó, Ádám ; Karádi, Zoltán ; Lénárd, L. / Role of D1 dopamine receptors of the ventral pallidum in inhibitory avoidance learning. In: Behavioural Brain Research. 2014 ; Vol. 270. pp. 131-136.
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