Role of complement in the pathomechanism of atherosclerotic vascular diseases

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In the first part of the review article authors summarize our knowledge on the role of complement in atherogenesis and the development of I/R injury as well as the complement activation products which contribute to these pathological processes. In the second part of the review authors highlight the complement dependent processes which participate at the pathomechanism of cerebrovascular diseases, the development of cerebral infarct in ischemic stroke and the restenosis which may occur a part of the patients who underwent eversion endartectomy operation. Literature data and the recently published data of the authors' group indicate that the complement system is strongly activated at the onset of the ischemic stroke and the extent of this activation is positively correlated with the bad outcome of the disease. This observation may be one of the starting points of the introduction of the complement activation-inhibiting therapy in ischemic stroke.

Original languageEnglish
Pages (from-to)2784-2793
Number of pages10
JournalMolecular Immunology
Volume46
Issue number14
DOIs
Publication statusPublished - Sep 2009

Fingerprint

Vascular Diseases
Complement Activation
Stroke
Cerebrovascular Disorders
Pathologic Processes
Atherosclerosis
Wounds and Injuries
Therapeutics

Keywords

  • Atherosclerosis
  • C5a
  • C5b-9
  • Complement
  • Stroke
  • Therapy

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Role of complement in the pathomechanism of atherosclerotic vascular diseases. / Széplaki, G.; Varga, L.; Füst, G.; Prohászka, Z.

In: Molecular Immunology, Vol. 46, No. 14, 09.2009, p. 2784-2793.

Research output: Contribution to journalArticle

@article{eb5d5860dcfb43b7ab6bdb13303ea5c3,
title = "Role of complement in the pathomechanism of atherosclerotic vascular diseases",
abstract = "In the first part of the review article authors summarize our knowledge on the role of complement in atherogenesis and the development of I/R injury as well as the complement activation products which contribute to these pathological processes. In the second part of the review authors highlight the complement dependent processes which participate at the pathomechanism of cerebrovascular diseases, the development of cerebral infarct in ischemic stroke and the restenosis which may occur a part of the patients who underwent eversion endartectomy operation. Literature data and the recently published data of the authors' group indicate that the complement system is strongly activated at the onset of the ischemic stroke and the extent of this activation is positively correlated with the bad outcome of the disease. This observation may be one of the starting points of the introduction of the complement activation-inhibiting therapy in ischemic stroke.",
keywords = "Atherosclerosis, C5a, C5b-9, Complement, Stroke, Therapy",
author = "G. Sz{\'e}plaki and L. Varga and G. F{\"u}st and Z. Proh{\'a}szka",
year = "2009",
month = "9",
doi = "10.1016/j.molimm.2009.04.028",
language = "English",
volume = "46",
pages = "2784--2793",
journal = "Molecular Immunology",
issn = "0161-5890",
publisher = "Elsevier Limited",
number = "14",

}

TY - JOUR

T1 - Role of complement in the pathomechanism of atherosclerotic vascular diseases

AU - Széplaki, G.

AU - Varga, L.

AU - Füst, G.

AU - Prohászka, Z.

PY - 2009/9

Y1 - 2009/9

N2 - In the first part of the review article authors summarize our knowledge on the role of complement in atherogenesis and the development of I/R injury as well as the complement activation products which contribute to these pathological processes. In the second part of the review authors highlight the complement dependent processes which participate at the pathomechanism of cerebrovascular diseases, the development of cerebral infarct in ischemic stroke and the restenosis which may occur a part of the patients who underwent eversion endartectomy operation. Literature data and the recently published data of the authors' group indicate that the complement system is strongly activated at the onset of the ischemic stroke and the extent of this activation is positively correlated with the bad outcome of the disease. This observation may be one of the starting points of the introduction of the complement activation-inhibiting therapy in ischemic stroke.

AB - In the first part of the review article authors summarize our knowledge on the role of complement in atherogenesis and the development of I/R injury as well as the complement activation products which contribute to these pathological processes. In the second part of the review authors highlight the complement dependent processes which participate at the pathomechanism of cerebrovascular diseases, the development of cerebral infarct in ischemic stroke and the restenosis which may occur a part of the patients who underwent eversion endartectomy operation. Literature data and the recently published data of the authors' group indicate that the complement system is strongly activated at the onset of the ischemic stroke and the extent of this activation is positively correlated with the bad outcome of the disease. This observation may be one of the starting points of the introduction of the complement activation-inhibiting therapy in ischemic stroke.

KW - Atherosclerosis

KW - C5a

KW - C5b-9

KW - Complement

KW - Stroke

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=68049127797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68049127797&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2009.04.028

DO - 10.1016/j.molimm.2009.04.028

M3 - Article

C2 - 19501908

AN - SCOPUS:68049127797

VL - 46

SP - 2784

EP - 2793

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

IS - 14

ER -