Role of cellulose in wood dust‐induced fibrosing alveo‐bronchiolitis in rat

Frzsébet Tátrai, Zoltán Adamis, Ute Böhm, Katalin Merétey, György Ungváry

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Our experiments suggest that in the development of plant dust‐induced fibrosing alveobronchiolitis—Scadding's fibrosing alveolitis—the cellulose content of plant dusts has a decisive aetiological role. Namely, the wood dust (pine) and the cellulose induced morphologically identical granulomatous inflammation and fibrosis, whereas the fibre‐free extract of wood dust did not cause pathological changes in the lungs. The induction of H2O2 and superoxide anion production, shown in vitro in leucocytes, probably has an important role in the development of fibrosis.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalJournal of Applied Toxicology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1 1995

Keywords

  • cellulose
  • fibrosing alveobronchiolitis
  • free radicals
  • rat
  • wood dust

ASJC Scopus subject areas

  • Toxicology

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