Role of CDK/cyclin complexes in transcription and RNA splicing

Pascal Loyer, Janeen H. Trembley, R. Katona, Vincent J. Kidd, Jill M. Lahti

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The production of mRNAs in all living organisms is an extremely complex process that includes multiple catalytic activities such as transcription, capping, splicing, polyadenylation, cleavage and export. All of these processes are controlled by a large group of proteins which form very dynamic complexes interacting with DNA and pre-mRNAs to coordinate these activities. Phosphorylations play a central role in regulating formation, activation and inactivation of these complexes. A growing number of protein kinases have been identified that are capable of phosphorylating proteins involved in mRNA production. Among them, Cyclin-dependent Kinases (CDKs) represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. CDK/cyclin complexes were first identified as crucial regulators of cell cycle progression. More recently, CDK/cyclin complexes have also been implicated in transcription and mRNA processing leading to the concept of an intricate network of CDK/cyclin complexes regulating cell cycle, transcription and mRNA processing via cross-talk between multiple CDKs. In this review, we discuss the role of CDK/cyclin-dependent phosphorylation in the regulation of transcription and RNA splicing and highlight recent findings that indicate the involvement of CDK/cyclin complexes in connecting transcription and RNA splicing.

Original languageEnglish
Pages (from-to)1033-1051
Number of pages19
JournalCellular Signalling
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2005

Fingerprint

RNA Splicing
Cyclins
Cyclin-Dependent Kinases
Messenger RNA
Cell Cycle
Phosphorylation
Polyadenylation
Protein-Serine-Threonine Kinases
RNA Precursors
Protein Kinases
Proteins
DNA

Keywords

  • CDK
  • Cyclins
  • Phosphorylation
  • Splicing
  • Transcription

ASJC Scopus subject areas

  • Cell Biology

Cite this

Role of CDK/cyclin complexes in transcription and RNA splicing. / Loyer, Pascal; Trembley, Janeen H.; Katona, R.; Kidd, Vincent J.; Lahti, Jill M.

In: Cellular Signalling, Vol. 17, No. 9, 09.2005, p. 1033-1051.

Research output: Contribution to journalArticle

Loyer, Pascal ; Trembley, Janeen H. ; Katona, R. ; Kidd, Vincent J. ; Lahti, Jill M. / Role of CDK/cyclin complexes in transcription and RNA splicing. In: Cellular Signalling. 2005 ; Vol. 17, No. 9. pp. 1033-1051.
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