Role of calcium-activated potassium channels in the regulation of basal and agonist-elevated tones in isolated conduit arteries: Short communication

J. Pataricza, Z. Márton, Z. Hegedus, Irén Krassói, A. Kun, A. Varró, J. Papp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Functional role of calcium-activated potassium (KCa) channels on the basal and agonist-elevated arterial tones was investigated in isolated rabbit aorta, porcine and canine coronary arteries as well as in human internal mammary artery. The vascular tones enhanced by contractile agents were increased further by preincubation of these conduit blood vessels with selective (charybdotoxin or iberiotoxin) or non-selective (tetraethylammonium) inhibitors of KCa channels. The basal tone (without an agonist) was increased only in the canine coronary artery. The results indicate a feed-back regulatory role of KCa channels counteracting the vasospasm of conduit arteries.

Original languageEnglish
Pages (from-to)263-265
Number of pages3
JournalActa Physiologica Hungarica
Volume91
Issue number3-4
DOIs
Publication statusPublished - 2004

Fingerprint

Calcium-Activated Potassium Channels
Blood Vessels
Canidae
Coronary Vessels
Arteries
Communication
Charybdotoxin
Tetraethylammonium
Mammary Arteries
Aorta
Swine
Rabbits
iberiotoxin

Keywords

  • Agonist-elevated tone
  • Basal tone
  • Calcium-activated potassium (K) channels
  • Charybdotoxin
  • Conduit arteries
  • Coronary arteries
  • Iberiotoxin
  • Internal mammary artery
  • Rabbit aorta
  • Tetraethylammonium

ASJC Scopus subject areas

  • Physiology

Cite this

Role of calcium-activated potassium channels in the regulation of basal and agonist-elevated tones in isolated conduit arteries : Short communication. / Pataricza, J.; Márton, Z.; Hegedus, Z.; Krassói, Irén; Kun, A.; Varró, A.; Papp, J.

In: Acta Physiologica Hungarica, Vol. 91, No. 3-4, 2004, p. 263-265.

Research output: Contribution to journalArticle

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AU - Papp, J.

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