Az antimikrobiális peptidek és a mintázatfelismero receptorok szerepe a bélrendszer homeosztázisának fenntartásában

Translated title of the contribution: Role of antimicrobial peptides (AMP) and pattern recognition receptors (PRR) in the intestinal mucosa homeostasis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Homeostasis and integrity of bowel mucosa is assured by well controlled mechanical, biochemical and immunological mechanisms. First line of defense is presented by the antimicrobial peptides (AMP), which form a continuous layer on the bowel surface, produced by intestinal specific (Paneth) and non-specific epithelial cells. AMPs have a significant antimicrobial, antifungal and antiviral, as well as immunomodulatory effects. Next line of defense is the pattern recognition receptors (PRR), which allows identifying conservative molecular patterns of different pathogens, and starts antimicrobial and inflammatory mechanisms through gene-expression induction. We review the most recent knowledge and studies concerning these mechanisms.

Original languageHungarian
Pages (from-to)2146-2149
Number of pages4
JournalOrvosi Hetilap
Volume150
Issue number47
DOIs
Publication statusPublished - 2009

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Pattern Recognition Receptors
Adenosine Monophosphate
Intestinal Mucosa
Antiviral Agents
Mucous Membrane
Homeostasis
Epithelial Cells
Gene Expression
Peptides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az antimikrobiális peptidek és a mintázatfelismero receptorok szerepe a bélrendszer homeosztázisának fenntartásában. / Lapis, K.

In: Orvosi Hetilap, Vol. 150, No. 47, 2009, p. 2146-2149.

Research output: Contribution to journalArticle

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