Role of adrenergic receptor subtypes in the control of human placental blood vessels

Béla Endre Resch, Eszter Ducza, Róbert Gáspár, George Falkay

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Statements of the Problem: The use of β2-Adrenergic Receptor (AR) agonists and the potential use of α1-AR blockers as tocolytics raise the question of how they influence placental circulation. The receptor profile was characterized via the amounts of the mRNA of α1-AR subtypes and β2-ARs. The mRNAs were detected by reverse transcription-polymerase chain reaction. Electric field stimulation (EFS) was applied to test the pharmacological reactivity of the placental vessels. Expressions of β2- and all subtypes of α1-AR mRNA were demonstrated in human placental vessels, and were significantly higher in the arteries. A significant difference was not found between the veins and the arteries as concerns the amount of α1D-AR mRNA. There was a preponderance of α1A- and α1B-AR mRNA as compared to α1D-AR mRNA both in the arteries and in the veins. β2-AR agonists and α1-AR antagonists antagonized the EFS-induced contractions of the placental arteries in a dose-dependent manner. These effects were significantly less marked on veins at all applied doses. Urapidil antagonized the EFS-induced contractions of both the placental arterial and vein rings in a dose-dependent manner. The β2-, α1A-, and α1B-AR are the important subtypes involved in the regulation of the contractility of the human term placental vessels. The possible increase in placental blood flow mediated by these ARs can even be beneficial during pregnancy. Accordingly, the use of β2-AR agonists and the potential use of α1-blockers as tocolytics seem safe on the basis of in vitro examinations as concerns the placental circulation.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalMolecular Reproduction and Development
Volume66
Issue number2
DOIs
Publication statusPublished - Oct 1 2003

Keywords

  • Adrenergic receptor subtypes
  • Electric field stimulation
  • Human placental blood vessels
  • RT-PCR

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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