Role of a structural glycoprotein of pseudorabies in virus virulence

T. C. Mettenleiter, L. Zsak, A. S. Kaplan, T. Ben-Porat, B. Lomniczi

Research output: Contribution to journalArticle

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Abstract

The virulence of deletion mutants of pseudorabies virus defective in the expression of glycoprotein gI, gp63, or both was tested in 1-day-old chickens and young pigs. In the absence of expression of gI, the virulence of a fully virulent laboratory strain, PrV(Ka), for 1-day-old chickens was reduced approximately fourfold. Inactivation of glycoprotein gp63 appeared also to affect the virulence of PrV(Ka) only slightly, as did inactivation of both gI and gp63. The level of reduction in virulence, however, was considerably more marked in Bartha 43/25aB4, a less virulent virus strain. Inactivation of the expression of gI in Bartha 43/25aB4 reduced virulence for chickens at least 100-fold. The results obtained when the virulence of the mutants for pigs was determined were compatible with those obtained for chickens. These results indicate that gI plays a role in virulence, but that it does so in conjunction with at least one other viral function (a function that is defective in Bartha 43/25aB4).

Original languageEnglish
Pages (from-to)4030-4032
Number of pages3
JournalJournal of Virology
Volume61
Issue number12
Publication statusPublished - 1987

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Suid Herpesvirus 1
Suid herpesvirus 1
Virulence
glycoproteins
virulence
Chickens
chickens
inactivation
Glycoproteins
Swine
mutants
swine
Bos taurus structural-GP protein
Viruses
viruses

ASJC Scopus subject areas

  • Immunology

Cite this

Mettenleiter, T. C., Zsak, L., Kaplan, A. S., Ben-Porat, T., & Lomniczi, B. (1987). Role of a structural glycoprotein of pseudorabies in virus virulence. Journal of Virology, 61(12), 4030-4032.

Role of a structural glycoprotein of pseudorabies in virus virulence. / Mettenleiter, T. C.; Zsak, L.; Kaplan, A. S.; Ben-Porat, T.; Lomniczi, B.

In: Journal of Virology, Vol. 61, No. 12, 1987, p. 4030-4032.

Research output: Contribution to journalArticle

Mettenleiter, TC, Zsak, L, Kaplan, AS, Ben-Porat, T & Lomniczi, B 1987, 'Role of a structural glycoprotein of pseudorabies in virus virulence', Journal of Virology, vol. 61, no. 12, pp. 4030-4032.
Mettenleiter TC, Zsak L, Kaplan AS, Ben-Porat T, Lomniczi B. Role of a structural glycoprotein of pseudorabies in virus virulence. Journal of Virology. 1987;61(12):4030-4032.
Mettenleiter, T. C. ; Zsak, L. ; Kaplan, A. S. ; Ben-Porat, T. ; Lomniczi, B. / Role of a structural glycoprotein of pseudorabies in virus virulence. In: Journal of Virology. 1987 ; Vol. 61, No. 12. pp. 4030-4032.
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