A katepszin B és a katepszin L viselkedése és szerepe a gyomorrákban.

Translated title of the contribution: Role and behavior of cathepsin B and cathepsin L in gastric cancer

L. Herszényi, M. Plebani, P. Carraro, M. De Paoli, G. Roveroni, M. Rugge, R. Cardin, R. Naccarato, F. Farinati

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Cathepsin B and cathepsin L--cysteine proteinases--may play an important role in cancer invasion and metastasis. The authors determined tissue antigen concentrations of cathepsins, using the ELISA method, in 25 patients with gastric cancer (17 males, 8 females, mean age 62, range 31-84). They evaluated the possible relationship that these proteinases may have with the presence of metastases, differentiation and histotype. Significantly higher cathepsin B and cathepsin L antigen levels were found: 1. in gastric cancer tissues vs. normal tissues distant from tumors (CATB: p < 0.05, CATL: p < 0.005); 2. in diffuse vs. intestinal type cancers (p < 0.05); 3. in patients with poorly vs. well-differentiated cancers (p < 0.05); in gastric cancers with vs. without metastasis (p < 0.05). Their results confirm that cathepsin B and L play an important role in gastric cancer invasion and metastasis. Considering the significantly higher cathepsins detected in cancers with metastasis, a poor differentiation and of diffuse histotype, these proteinases could be useful for identification gastric cancer patients with a poor prognosis.

Translated title of the contributionRole and behavior of cathepsin B and cathepsin L in gastric cancer
Original languageHungarian
Pages (from-to)1315-1318
Number of pages4
JournalOrvosi hetilap
Volume136
Issue number25
Publication statusPublished - Jun 18 1995

ASJC Scopus subject areas

  • Medicine(all)

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    Herszényi, L., Plebani, M., Carraro, P., De Paoli, M., Roveroni, G., Rugge, M., Cardin, R., Naccarato, R., & Farinati, F. (1995). A katepszin B és a katepszin L viselkedése és szerepe a gyomorrákban. Orvosi hetilap, 136(25), 1315-1318.