Rod models of DNA: Sequence-dependent anisotropic elastic modelling of local bending phenomena

Mircea G. Munteanu, Kristian Vlahovicek, Subbiah Parthasarathy, I. Simon, Sándor Pongor

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Local bending phenomena can be predicted by elastic models that incorporate sequence-dependent anisotropic-bendability (SDAB). SDAB models consider DNA to be an initially straight, segmented, elastic rod, in which the flexibility of each segment is greater towards the major groove than it is in other directions. While local bending can be predicted by static- geometry models as well, SDAB models, in addition, qualitatively explain such phenomena as the affinity of protein binding and kinking. A set of prediction tools is available at http://www.icgeb.trieste.it/dna Copyright (C) 1998 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalTrends in Biochemical Sciences
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 1 1998

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DNA sequences
Protein Binding
Formability
DNA
Geometry
Direction compound

ASJC Scopus subject areas

  • Biochemistry

Cite this

Rod models of DNA : Sequence-dependent anisotropic elastic modelling of local bending phenomena. / Munteanu, Mircea G.; Vlahovicek, Kristian; Parthasarathy, Subbiah; Simon, I.; Pongor, Sándor.

In: Trends in Biochemical Sciences, Vol. 23, No. 9, 01.09.1998, p. 341-347.

Research output: Contribution to journalArticle

Munteanu, Mircea G. ; Vlahovicek, Kristian ; Parthasarathy, Subbiah ; Simon, I. ; Pongor, Sándor. / Rod models of DNA : Sequence-dependent anisotropic elastic modelling of local bending phenomena. In: Trends in Biochemical Sciences. 1998 ; Vol. 23, No. 9. pp. 341-347.
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