Robust tight glycaemic control of ICU patients

L. Kovács, Péter Szalay, Balázs Benyó, J. Geoffrey Chase

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Intensive care is one of the most challenging areas of modern medicine. Maintenance of glucose levels in intensive care unit (ICU) patients via control of insulin inputs is currently an active research field. The current paper presents the analysis of postmodern and nonlinear control methods for tight glycaemic control (TGC) under intensive care. Using a clinically validated ICU metabolic system model's redefined version, an H.-type robust controller is proposed and compared with a nonconservative complex μ-synthesis method, where robust stability and nominal performance is met under multiplicative uncertainty. The model is rewritten in affine parameter varying form by choosing scheduling parameters and a quasi Affine Linear Parameter Varying (qALPV) controller is designed assuring performance and stability requirements. Closed loop simulation results are tested under MATLAB for real clinical dataset.

Original languageEnglish
Title of host publicationIFAC Proceedings Volumes (IFAC-PapersOnline)
Pages4995-5000
Number of pages6
Volume18
EditionPART 1
DOIs
Publication statusPublished - 2011
Event18th IFAC World Congress - Milano, Italy
Duration: Aug 28 2011Sep 2 2011

Other

Other18th IFAC World Congress
CountryItaly
CityMilano
Period8/28/119/2/11

Fingerprint

Intensive care units
Controllers
Insulin
MATLAB
Medicine
Glucose
Scheduling

Keywords

  • μ-synthesis
  • Diabetes
  • H. control
  • QALPV
  • Tight glycaemic control

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Kovács, L., Szalay, P., Benyó, B., & Chase, J. G. (2011). Robust tight glycaemic control of ICU patients. In IFAC Proceedings Volumes (IFAC-PapersOnline) (PART 1 ed., Vol. 18, pp. 4995-5000) https://doi.org/10.3182/20110828-6-IT-1002.02852

Robust tight glycaemic control of ICU patients. / Kovács, L.; Szalay, Péter; Benyó, Balázs; Chase, J. Geoffrey.

IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 18 PART 1. ed. 2011. p. 4995-5000.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kovács, L, Szalay, P, Benyó, B & Chase, JG 2011, Robust tight glycaemic control of ICU patients. in IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 edn, vol. 18, pp. 4995-5000, 18th IFAC World Congress, Milano, Italy, 8/28/11. https://doi.org/10.3182/20110828-6-IT-1002.02852
Kovács L, Szalay P, Benyó B, Chase JG. Robust tight glycaemic control of ICU patients. In IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 ed. Vol. 18. 2011. p. 4995-5000 https://doi.org/10.3182/20110828-6-IT-1002.02852
Kovács, L. ; Szalay, Péter ; Benyó, Balázs ; Chase, J. Geoffrey. / Robust tight glycaemic control of ICU patients. IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 18 PART 1. ed. 2011. pp. 4995-5000
@inproceedings{121e8254b298449984aa5e900a073c42,
title = "Robust tight glycaemic control of ICU patients",
abstract = "Intensive care is one of the most challenging areas of modern medicine. Maintenance of glucose levels in intensive care unit (ICU) patients via control of insulin inputs is currently an active research field. The current paper presents the analysis of postmodern and nonlinear control methods for tight glycaemic control (TGC) under intensive care. Using a clinically validated ICU metabolic system model's redefined version, an H.-type robust controller is proposed and compared with a nonconservative complex μ-synthesis method, where robust stability and nominal performance is met under multiplicative uncertainty. The model is rewritten in affine parameter varying form by choosing scheduling parameters and a quasi Affine Linear Parameter Varying (qALPV) controller is designed assuring performance and stability requirements. Closed loop simulation results are tested under MATLAB for real clinical dataset.",
keywords = "μ-synthesis, Diabetes, H. control, QALPV, Tight glycaemic control",
author = "L. Kov{\'a}cs and P{\'e}ter Szalay and Bal{\'a}zs Beny{\'o} and Chase, {J. Geoffrey}",
year = "2011",
doi = "10.3182/20110828-6-IT-1002.02852",
language = "English",
isbn = "9783902661937",
volume = "18",
pages = "4995--5000",
booktitle = "IFAC Proceedings Volumes (IFAC-PapersOnline)",
edition = "PART 1",

}

TY - GEN

T1 - Robust tight glycaemic control of ICU patients

AU - Kovács, L.

AU - Szalay, Péter

AU - Benyó, Balázs

AU - Chase, J. Geoffrey

PY - 2011

Y1 - 2011

N2 - Intensive care is one of the most challenging areas of modern medicine. Maintenance of glucose levels in intensive care unit (ICU) patients via control of insulin inputs is currently an active research field. The current paper presents the analysis of postmodern and nonlinear control methods for tight glycaemic control (TGC) under intensive care. Using a clinically validated ICU metabolic system model's redefined version, an H.-type robust controller is proposed and compared with a nonconservative complex μ-synthesis method, where robust stability and nominal performance is met under multiplicative uncertainty. The model is rewritten in affine parameter varying form by choosing scheduling parameters and a quasi Affine Linear Parameter Varying (qALPV) controller is designed assuring performance and stability requirements. Closed loop simulation results are tested under MATLAB for real clinical dataset.

AB - Intensive care is one of the most challenging areas of modern medicine. Maintenance of glucose levels in intensive care unit (ICU) patients via control of insulin inputs is currently an active research field. The current paper presents the analysis of postmodern and nonlinear control methods for tight glycaemic control (TGC) under intensive care. Using a clinically validated ICU metabolic system model's redefined version, an H.-type robust controller is proposed and compared with a nonconservative complex μ-synthesis method, where robust stability and nominal performance is met under multiplicative uncertainty. The model is rewritten in affine parameter varying form by choosing scheduling parameters and a quasi Affine Linear Parameter Varying (qALPV) controller is designed assuring performance and stability requirements. Closed loop simulation results are tested under MATLAB for real clinical dataset.

KW - μ-synthesis

KW - Diabetes

KW - H. control

KW - QALPV

KW - Tight glycaemic control

UR - http://www.scopus.com/inward/record.url?scp=84866759296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866759296&partnerID=8YFLogxK

U2 - 10.3182/20110828-6-IT-1002.02852

DO - 10.3182/20110828-6-IT-1002.02852

M3 - Conference contribution

AN - SCOPUS:84866759296

SN - 9783902661937

VL - 18

SP - 4995

EP - 5000

BT - IFAC Proceedings Volumes (IFAC-PapersOnline)

ER -