Robust Microcircuit Synchronization by Inhibitory Connections

A. Szűcs, Ramon Huerta, Mikhail I. Rabinovich, Allen I. Selverston

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. We use a well known compact motor network, the lobster pyloric CPG to study principles of intercircuit synchronization. We couple separate pyloric circuits obtained from two animals via artificial synapses and observe how their synchronization depends on the topology and kinetic parameters of the computer-generated synapses. Stable in-phase synchronization appears when electrically coupling the pacemaker groups of the two networks, but reciprocal inhibitory connections produce more robust and regular cooperative activity. Contralateral inhibitory connections offer effective synchronization and flexible setting of the burst phases of the interacting networks. We also show that a conductance-based mathematical model of the coupled circuits correctly reproduces the observed dynamics illustrating the generality of the phenomena.

Original languageEnglish
Pages (from-to)439-453
Number of pages15
JournalNeuron
Volume61
Issue number3
DOIs
Publication statusPublished - Feb 12 2009

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Central Pattern Generators
Synapses
Biological Models
Theoretical Models
Brain

Keywords

  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Szűcs, A., Huerta, R., Rabinovich, M. I., & Selverston, A. I. (2009). Robust Microcircuit Synchronization by Inhibitory Connections. Neuron, 61(3), 439-453. https://doi.org/10.1016/j.neuron.2008.12.032

Robust Microcircuit Synchronization by Inhibitory Connections. / Szűcs, A.; Huerta, Ramon; Rabinovich, Mikhail I.; Selverston, Allen I.

In: Neuron, Vol. 61, No. 3, 12.02.2009, p. 439-453.

Research output: Contribution to journalArticle

Szűcs, A, Huerta, R, Rabinovich, MI & Selverston, AI 2009, 'Robust Microcircuit Synchronization by Inhibitory Connections', Neuron, vol. 61, no. 3, pp. 439-453. https://doi.org/10.1016/j.neuron.2008.12.032
Szűcs, A. ; Huerta, Ramon ; Rabinovich, Mikhail I. ; Selverston, Allen I. / Robust Microcircuit Synchronization by Inhibitory Connections. In: Neuron. 2009 ; Vol. 61, No. 3. pp. 439-453.
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