RNA processing in prokaryotic cells

David Apirion, A. Miczák

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

RNA processing in Escherichia coli and some of its phages is reviewed here, with primary emphasis on rRNA and tRNA processing. Three enzymes, RNase III, RNase E and RNase P are responsible for most of the primary endonucleolytic RNA processing events. The first two are proteins, while RNase P is a ribozyme. These three enzymes have unique functions and in their absence, the cleavage events they catalyze are not performed. On the other hand a relatively large number of exonucleases participate in the trimming of the 3′ ends of tRNA precursor molecules and they can substitute for each other. Primary processing is the first event that happens to the nascent RNA molecule, while in secondary RNA processing, the substrate is a product of a primary processing event. Although most RNA processing occurs in RNP particles, it seems that only in secondary RNA processing is the RNP particle required for the reaction. Bacteria and especially bacteriophages contain self-splicing introns which in cases were probably acquired from other species.

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalBioEssays
Volume15
Issue number2
Publication statusPublished - 1993

Fingerprint

Prokaryotic Cells
prokaryotic cells
RNA
Processing
Ribonuclease P
bacteriophages
Bacteriophages
Ribonuclease III
Exonucleases
Catalytic RNA
RNA Precursors
Enzymes
enzymes
Transfer RNA
Introns
Molecules
Trimming
introns
ribosomal RNA
Escherichia coli

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Developmental Biology
  • Neuroscience (miscellaneous)

Cite this

Apirion, D., & Miczák, A. (1993). RNA processing in prokaryotic cells. BioEssays, 15(2), 113-120.

RNA processing in prokaryotic cells. / Apirion, David; Miczák, A.

In: BioEssays, Vol. 15, No. 2, 1993, p. 113-120.

Research output: Contribution to journalArticle

Apirion, D & Miczák, A 1993, 'RNA processing in prokaryotic cells', BioEssays, vol. 15, no. 2, pp. 113-120.
Apirion, David ; Miczák, A. / RNA processing in prokaryotic cells. In: BioEssays. 1993 ; Vol. 15, No. 2. pp. 113-120.
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