RNA interference links oxidative stress to the inhibition of heat stress adaptation

Zoltán Spiró, Mehmet Alper Arslan, Milán Somogyvári, Minh Tu Nguyen, Arne Smolders, Balázs Dancsó, Nóra Németh, Zsuzsanna Elek, Bart P. Braeckman, Péter Csermely, Csaba Soti

Research output: Contribution to journalArticle

10 Citations (Scopus)


Increased oxidative stress is associated with various diseases and aging, while adaptation to heat stress is an important determinant of survival and contributes to longevity. However, the impact of oxidative stress on heat resistance remains largely unclear. Aim: In this study we investigated how oxidative stress impinges on heat stress responses. Results: We report that hydrogen-peroxide (H2O2) pretreatment inhibits both acquired thermotolerance and heat-induced Hsp70 expression in mammalian cells, as well as acquired thermotolerance in the nematode Caenorhabditis elegans, via RNA interference. Moreover, we demonstrate that elimination of RNA interference by silencing key enzymes in microRNA biogenesis, dcr-1 or pash-1, restores the diminished intrinsic thermotolerance of aged and H2O 2-elimination compromised (catalase-2 and peroxiredoxin-2 deficient) worms. Innovation and Conclusion: These results uncover a novel post-transcriptional element in the regulation of heat stress adaptation under oxidative conditions that may have implications in disease susceptibility and aging. Antioxid. Redox Signal.

Original languageEnglish
Pages (from-to)890-901
Number of pages12
JournalAntioxidants and Redox Signaling
Issue number6
Publication statusPublished - Sep 15 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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  • Cite this

    Spiró, Z., Arslan, M. A., Somogyvári, M., Nguyen, M. T., Smolders, A., Dancsó, B., Németh, N., Elek, Z., Braeckman, B. P., Csermely, P., & Soti, C. (2012). RNA interference links oxidative stress to the inhibition of heat stress adaptation. Antioxidants and Redox Signaling, 17(6), 890-901. https://doi.org/10.1089/ars.2011.4161