The prevalence of type 2 diabetes mellitus in children and adolescents is increasing throughout the world. Early detection of blood glucose abnormalities is essential to improve long term prognosis of type 2 diabetes, as intervention strategies could be the most effective in youngsters. Aim: To assess the prevalence of blood glucose abnormalities in asymptomatic adolescents having increased risk of diabetes, a screening program of the Hungarian Diabetes Association has been carried out in pediatric primary care setting. Methods: 660 adolescents aged 12-18 years recruited from general pediatric practices were involved in the study. Risk assessment was performed by a questionnaire compiled according to the ADA recommendation for testing type 2 diabetes in childhood. Fasting plasma glucose and OGTT were performed in adolescents having increased risk for type 2 diabetes (overweight plus two additional clinical risk factors) and results were assessed according to WHO criteria. Results: 285 adolescents of 660 were selected with increased risk for type 2 diabetes established by questionnaire (age: 15.2±1.8 years, BMI: 30.2±4.2 kg/m 2 , 141 males). Among subjects with increased risk, 16 (5.6%) had any type of blood glucose abnormalities: 4 (1.40%) IFG, 5 (1.75%) IFG+IGT, 6 (2.11%) IGT and 1 (0.35%) type 2 diabetes. Assessing the effect of clinical variables, increased BMI proved to be the strongest predictor of the diabetes risk [OR (95% CI): 1.216 (1.174-1.258), p<0.0001]. Conclusions: Screening procedure among asymptomatic adolescents with high risk of type 2 diabetes in the general pediatric practice is a simple and effective method for early detection of blood glucose abnormalities. Screening for type 2 diabetes in adolescents at risk should be encouraged in Hungary, and should be performed in pediatric primary care setting.
|Translated title of the contribution||Risk-stratified screening for diabetes in adolescents: Results of the first investigation in Hungary|
|Number of pages||6|
|Publication status||Published - Oct 1 2010|
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