Risk of specific congenital abnormalities in offspring of women with diabetes

Gunnar Lauge Nielsen, B. Nørgard, E. Puho, K. J. Rothman, H. T. Sørensen, A. E. Czeizel

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Aims: To assess the extent to which the increased risk of congenital abnormalities seen in women with pre-gestational insulin-treated diabetes mellitus is unspecific or related to the embryology of specific organs. Methods: Cases with congenital abnormalities were identified in the population-based Hungarian Congenital Abnormality Registry from 1980 to 1996 with two newborn children without congenital abnormality selected from the National Birth Registry as controls. We adjusted for parity, maternal age, and use of antipsychotic drugs. Results: Among cases we found 63/22 843 babies with maternal diabetes compared with 50/38 151 in the control group [adjusted prevalence odds ratio (POR) 2.1; 95% CI 1.5-3.1]. The association was strongest for the following congenital abnormalities: renal agenesis (POR: 14.8; 95% CI, 3.5-62.1), obstructive congenital abnormalities of the urinary tract (POR: 4.3; 95% CI, 1.3-13.9), cardiovascular congenital abnormalities (POR: 3.4; 95% CI, 2.0-5.7), and multiple congenital abnormalities (POR: 5.0; 95% CI, 2.4-10.2). Conclusions: These data indicate that pre-gestational maternal diabetes is associated with strong teratogenic effects on the kidney, urinary tract, and heart, and strongly associated with multiple congenital abnormalities. We found no material association between diabetes and spinal congenital abnormalities and limb deficiencies.

Original languageEnglish
Pages (from-to)693-696
Number of pages4
JournalDiabetic Medicine
Volume22
Issue number6
DOIs
Publication statusPublished - Jun 1 2005

Keywords

  • Maternal diabetes
  • Specific congenital abnormalities

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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