Risk of relapse phenotype recurrence in multiple sclerosis

Tomas Kalincik, Katherine Buzzard, Vilija Jokubaitis, Maria Trojano, Pierre Duquette, Guillermo Izquierdo, Marc Girard, Alessandra Lugaresi, Pierre Grammond, Francois Grand'Maison, Celia Oreja-Guevara, Cavit Boz, Raymond Hupperts, Thor Petersen, Giorgio Giuliani, Gerardo Iuliano, Jeannette Lechner-Scott, Michael Barnett, Roberto Bergamaschi, Vincent Van PeschMaria Pia Amato, Erik Van Munster, Ricardo Fernandez-Bolanos, Freek Verheul, Marcela Fiol, Edgardo Cristiano, Mark Slee, Maria Edite Rio, Daniele Spitaleri, Raed Alroughani, Orla Gray, Maria Laura Saladino, Sholmo Flechter, Joseph Herbert, Jose Antonio Cabrera-Gomez, Norbert Vella, Mark Paine, Cameron Shaw, Fraser Moore, Steve Vucic, Aldo Savino, Bhim Singhal, Tatjana Petkovska-Boskova, John Parratt, Carmen Adella Sirbu, C. Rózsa, Danny Liew, Helmut Butzkueven

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objectives: The aim was to analyse risk of relapse phenotype recurrence in multiple sclerosis and to characterise the effect of demographic and clinical features on this phenotype. Methods: Information about relapses was collected using MSBase, an international observational registry. Associations between relapse phenotypes and history of similar relapses or patient characteristics were tested with multivariable logistic regression models. Tendency of relapse phenotypes to recur sequentially was assessed with principal component analysis. Results: Among 14,969 eligible patients (89,949 patient-years), 49,279 phenotypically characterised relapses were recorded. Visual and brainstem relapses occurred more frequently in early disease and in younger patients. Sensory relapses were more frequent in early or non-progressive disease. Pyramidal, sphincter and cerebellar relapses were more common in older patients and in progressive disease. Women presented more often with sensory or visual symptoms. Men were more prone to pyramidal, brainstem and cerebellar relapses. Importantly, relapse phenotype was predicted by the phenotypes of previous relapses. (OR = 1.8-5, p = 10-14). Sensory, visual and brainstem relapses showed better recovery than other relapse phenotypes. Relapse severity increased and the ability to recover decreased with age or more advanced disease. Conclusion: Relapse phenotype was associated with demographic and clinical characteristics, with phenotypic recurrence significantly more common than expected by chance.

Original languageEnglish
Pages (from-to)1511-1522
Number of pages12
JournalMultiple Sclerosis
Volume20
Issue number11
DOIs
Publication statusPublished - Oct 19 2014

Fingerprint

Multiple Sclerosis
Phenotype
Recurrence
Brain Stem
Logistic Models
Demography
Principal Component Analysis
Registries

Keywords

  • MSBase
  • Multiple sclerosis
  • phenotype
  • presentation of neurological diseases
  • prognosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Kalincik, T., Buzzard, K., Jokubaitis, V., Trojano, M., Duquette, P., Izquierdo, G., ... Butzkueven, H. (2014). Risk of relapse phenotype recurrence in multiple sclerosis. Multiple Sclerosis, 20(11), 1511-1522. https://doi.org/10.1177/1352458514528762

Risk of relapse phenotype recurrence in multiple sclerosis. / Kalincik, Tomas; Buzzard, Katherine; Jokubaitis, Vilija; Trojano, Maria; Duquette, Pierre; Izquierdo, Guillermo; Girard, Marc; Lugaresi, Alessandra; Grammond, Pierre; Grand'Maison, Francois; Oreja-Guevara, Celia; Boz, Cavit; Hupperts, Raymond; Petersen, Thor; Giuliani, Giorgio; Iuliano, Gerardo; Lechner-Scott, Jeannette; Barnett, Michael; Bergamaschi, Roberto; Van Pesch, Vincent; Amato, Maria Pia; Van Munster, Erik; Fernandez-Bolanos, Ricardo; Verheul, Freek; Fiol, Marcela; Cristiano, Edgardo; Slee, Mark; Rio, Maria Edite; Spitaleri, Daniele; Alroughani, Raed; Gray, Orla; Saladino, Maria Laura; Flechter, Sholmo; Herbert, Joseph; Cabrera-Gomez, Jose Antonio; Vella, Norbert; Paine, Mark; Shaw, Cameron; Moore, Fraser; Vucic, Steve; Savino, Aldo; Singhal, Bhim; Petkovska-Boskova, Tatjana; Parratt, John; Sirbu, Carmen Adella; Rózsa, C.; Liew, Danny; Butzkueven, Helmut.

In: Multiple Sclerosis, Vol. 20, No. 11, 19.10.2014, p. 1511-1522.

Research output: Contribution to journalArticle

Kalincik, T, Buzzard, K, Jokubaitis, V, Trojano, M, Duquette, P, Izquierdo, G, Girard, M, Lugaresi, A, Grammond, P, Grand'Maison, F, Oreja-Guevara, C, Boz, C, Hupperts, R, Petersen, T, Giuliani, G, Iuliano, G, Lechner-Scott, J, Barnett, M, Bergamaschi, R, Van Pesch, V, Amato, MP, Van Munster, E, Fernandez-Bolanos, R, Verheul, F, Fiol, M, Cristiano, E, Slee, M, Rio, ME, Spitaleri, D, Alroughani, R, Gray, O, Saladino, ML, Flechter, S, Herbert, J, Cabrera-Gomez, JA, Vella, N, Paine, M, Shaw, C, Moore, F, Vucic, S, Savino, A, Singhal, B, Petkovska-Boskova, T, Parratt, J, Sirbu, CA, Rózsa, C, Liew, D & Butzkueven, H 2014, 'Risk of relapse phenotype recurrence in multiple sclerosis', Multiple Sclerosis, vol. 20, no. 11, pp. 1511-1522. https://doi.org/10.1177/1352458514528762
Kalincik T, Buzzard K, Jokubaitis V, Trojano M, Duquette P, Izquierdo G et al. Risk of relapse phenotype recurrence in multiple sclerosis. Multiple Sclerosis. 2014 Oct 19;20(11):1511-1522. https://doi.org/10.1177/1352458514528762
Kalincik, Tomas ; Buzzard, Katherine ; Jokubaitis, Vilija ; Trojano, Maria ; Duquette, Pierre ; Izquierdo, Guillermo ; Girard, Marc ; Lugaresi, Alessandra ; Grammond, Pierre ; Grand'Maison, Francois ; Oreja-Guevara, Celia ; Boz, Cavit ; Hupperts, Raymond ; Petersen, Thor ; Giuliani, Giorgio ; Iuliano, Gerardo ; Lechner-Scott, Jeannette ; Barnett, Michael ; Bergamaschi, Roberto ; Van Pesch, Vincent ; Amato, Maria Pia ; Van Munster, Erik ; Fernandez-Bolanos, Ricardo ; Verheul, Freek ; Fiol, Marcela ; Cristiano, Edgardo ; Slee, Mark ; Rio, Maria Edite ; Spitaleri, Daniele ; Alroughani, Raed ; Gray, Orla ; Saladino, Maria Laura ; Flechter, Sholmo ; Herbert, Joseph ; Cabrera-Gomez, Jose Antonio ; Vella, Norbert ; Paine, Mark ; Shaw, Cameron ; Moore, Fraser ; Vucic, Steve ; Savino, Aldo ; Singhal, Bhim ; Petkovska-Boskova, Tatjana ; Parratt, John ; Sirbu, Carmen Adella ; Rózsa, C. ; Liew, Danny ; Butzkueven, Helmut. / Risk of relapse phenotype recurrence in multiple sclerosis. In: Multiple Sclerosis. 2014 ; Vol. 20, No. 11. pp. 1511-1522.
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AU - Buzzard, Katherine

AU - Jokubaitis, Vilija

AU - Trojano, Maria

AU - Duquette, Pierre

AU - Izquierdo, Guillermo

AU - Girard, Marc

AU - Lugaresi, Alessandra

AU - Grammond, Pierre

AU - Grand'Maison, Francois

AU - Oreja-Guevara, Celia

AU - Boz, Cavit

AU - Hupperts, Raymond

AU - Petersen, Thor

AU - Giuliani, Giorgio

AU - Iuliano, Gerardo

AU - Lechner-Scott, Jeannette

AU - Barnett, Michael

AU - Bergamaschi, Roberto

AU - Van Pesch, Vincent

AU - Amato, Maria Pia

AU - Van Munster, Erik

AU - Fernandez-Bolanos, Ricardo

AU - Verheul, Freek

AU - Fiol, Marcela

AU - Cristiano, Edgardo

AU - Slee, Mark

AU - Rio, Maria Edite

AU - Spitaleri, Daniele

AU - Alroughani, Raed

AU - Gray, Orla

AU - Saladino, Maria Laura

AU - Flechter, Sholmo

AU - Herbert, Joseph

AU - Cabrera-Gomez, Jose Antonio

AU - Vella, Norbert

AU - Paine, Mark

AU - Shaw, Cameron

AU - Moore, Fraser

AU - Vucic, Steve

AU - Savino, Aldo

AU - Singhal, Bhim

AU - Petkovska-Boskova, Tatjana

AU - Parratt, John

AU - Sirbu, Carmen Adella

AU - Rózsa, C.

AU - Liew, Danny

AU - Butzkueven, Helmut

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KW - prognosis

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